Document Detail


Developmental and Diurnal Expression of the Synaptosomal-Associated Protein 25 (Snap25) in the Rat Pineal Gland.
MedLine Citation:
PMID:  23135794     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Snap25 (synaptosomal-associated protein) is a 25 kDa protein, belonging to the SNARE-family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) of proteins, essential for synaptic and secretory vesicle exocytosis. Snap25 has by immunohistochemistry been demonstrated in the rat pineal gland but the biological importance of this is unknown. In this study, we demonstrate a high expression of mRNA encoding Snap25 in all parts of the rat pineal complex, the superficial-, and deep-pineal gland, as well as in the pineal stalk. Snap25 showed a low pineal expression during embryonic stages with a strong increase in expression levels just after birth. The expression showed no day/night variations. Neither removal of the sympathetic input to the pineal gland by superior cervical ganglionectomy nor bilateral decentralization of the superior cervical ganglia significantly affected the expression of Snap25 in the gland. The pineal expression levels of Snap25 were not changed following intraperitoneal injection of isoproterenol. The strong expression of Snap25 in the pineal gland suggests the presence of secretory granules and microvesicles in the rat pinealocyte supporting the concept of a vesicular release. At the transcriptional level, this Snap25-based release mechanism does not exhibit any diurnal rhythmicity and is regulated independently of the sympathetic nervous input to the gland.
Authors:
Anna S Karlsen; Martin F Rath; Kristian Rohde; Trine Toft; Morten Møller
Related Documents :
16629904 - Does mper2 protein oscillate without its coding mrna cycling?: post-transcriptional reg...
24560704 - Changes in the responsiveness of hypothalamic prokineticin 2 mrna expression to food de...
25009584 - Chinese medicinal formula, qinggan huoxue recipe protects rats from alcoholic liver dis...
8478214 - Zonal expression of the glucokinase gene in rat liver. dynamics during the daily feedin...
23134774 - A model of estrogen-related gene expression reveals non-linear effects in transcription...
11303904 - Frizzled 2 is transiently expressed in neural crest-containing areas during development...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark, annakarlsen@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization.
Next Document:  Phases of health promotion implementation into the Scottish school system.