| Developmental Biology of Coxiella burnetii. | |
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MedLine Citation:
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PMID: 22711635 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The biphasic developmental cycle of Coxiella burnetii is central to the pathogen's natural history and survival. A small, dormant cell morphotype (the small-cell variant or SCV) allows this obligate intracellular bacterium to persist for extended periods outside of host cells, resist environmental conditions that would be lethal to most prokaryotes, and is the major infectious stage encountered by eukaryotic hosts. In contrast, a large, metabolically-active morphotype (the large-cell variant or LCV) provides for replication of the agent within acidified parasitophorous vacuoles (PVs) of a host cell. The marked physiological changes, differential gene expression, and the regulatory and structural components involved in Coxiella's morphogenesis from LCV to SCV and back to the LCV are fascinating attributes of the pathogen and are reviewed in this chapter. |
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Authors:
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Michael F Minnick; Rahul Raghavan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 984 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 231-48 Citation Subset: IM |
Affiliation:
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Division of Biological Sciences, The University of Montana, Missoula, MT, 59812, USA, mike.minnick@mso.umt.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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