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Developmental Assessment of Infants with Biliary Atresia: Differences between Males and Females.
MedLine Citation:
PMID:  22516863     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: To investigate whether male and female infants with biliary atresia differ cognitively and to confirm previously documented developmental lags in infants with biliary atresia prior to liver transplantation. METHODS:: With the Mullen Scales of Early Learning (MSEL), we examined 21 female and 12 male infants (ages 3 - 20 months) with biliary atresia, comparing scores across indices by gender and correlating MSEL scores with standard clinical and biochemical parameters. RESULTS:: Overall, both males and females were found to be quite vulnerable to developmental lags in the areas of expressive language and gross motor. In comparison to their male peers, females were found to be weaker in the area of visual reception skills (p = 0.05) with a trend found for expressive language (p = 0.08). Females were also found to have higher C-bilirubin levels and to be of shorter length. Growth parameters were found to be correlated with expressive language scores. International normalized ratio (INR) was found to be correlated with gross motor performance and with a trend also noted for fine motor skills. Age at Kasai predicted receptive language skills. CONCLUSIONS:: As has been previously shown, infants with biliary atresia appear to be vulnerable to developmental lags prior to transplantation. In particular, female infants appear to be vulnerable to cognitive and skill delays in comparison to their male peers. C-bilirubin levels may play a role in this increased vulnerability for females.
Authors:
Susan E Caudle; Jennifer M Katzenstein; Saul Karpen; McLin Valérie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Psychology Service, Texas Children's Hospital, Section of Psychology, Baylor College of Medicine, Houston, Texas †Indiana University School of Medicine, Indiana University Health, Department of Neurology, Section of Neuropsychology, Indianapolis, IN ‡Nutrition and Gastroenterology, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, Texas §Unité de Gastroentérologie Pédiatrique, Hôpital des Enfants, Geneva, Switzerland.
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