Document Detail

Developmental Analysis of the Achaete-Scute System of DROSOPHILA MELANOGASTER.
MedLine Citation:
PMID:  17248807     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The interpretation of the wild-type function of a gene depends on our knowledge of the phenotype caused by its absence. We have first defined the genetic extent of the achaete-scute system by studying the phenotype of different terminal and intercalary deficiencies including these genes. When these deficiencies were lethal, we have defined the phenoeffective phase of lethality and studied their phenotype in genetic mosaics (gynandromorphs and mitotic recombination clones). The achaete-scute system affects two functions, one necessary for the differentiation of the embryonic (central?) nervous system and the other necessary for the differentiation of peripheral nervous elements of the chaetes and sensillae of the adult cuticle. The possibility that these functions correspond to differential expression of a single mechanism is discussed.
A García-Bellido; P Santamaria
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genetics     Volume:  88     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1978 Mar 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-06-28     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-86     Citation Subset:  -    
Centro de Biología Molecular, C.S.I.C., Facultad de Ciencias, C-X, Universidad Autónoma de Madrid, Madrid- 34, Spain.
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