Document Detail


Development of zero-link polymers of hemoglobin, which do not extravasate and do not induce pressure increases upon infusion.
MedLine Citation:
PMID:  17364467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intramolecular crosslink of hemoglobin tetramers solved the problem of urine elimination and short intravascular retention time of cell free hemoglobin infusion. It also produced a family of crosslinked hemoglobins with P50 between 18 and 30 mmHg. However, it did not solve the problem of MAP increases in infused animals. It was proven that extravasation of hemoglobin into interstitial fluid was responsible for MAP increases. Extravasation and the MAP increase was avoided using a hemoglobin polymer with average size near 25 MDa. In spite of a very high oxygen affinity, this polymer delivered oxygen to tissues, producing either vasodilation or vasoconstriction according to oxygen needs. It was also proven that cell free hemoglobins are more efficient than red cells in delivering oxygen to tissues.
Authors:
Enrico Bucci; Herman Kwansa; Raymond C Koehler; Barbara Matheson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  35     ISSN:  1073-1199     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-11-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Blood Pressure / drug effects*
Blood Substitutes / administration & dosage,  chemistry*,  pharmacokinetics*
Cats
Cattle
Cross-Linking Reagents
Hemoglobins / administration & dosage,  chemistry*,  pharmacokinetics*
Molecular Weight
Oxygen / metabolism
Polymers
Rabbits
Rats
Grant Support
ID/Acronym/Agency:
R01 NS038684/NS/NINDS NIH HHS; R01 NS038684-08/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Cross-Linking Reagents; 0/Hemoglobins; 0/Polymers; 0/hemoglobin polymer; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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