Document Detail


Development of vitiligo during melanoma treatment with a novel survivin inhibitor: a case report and review of the literature.
MedLine Citation:
PMID:  19335434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The development of vitiligo has been associated with an improved clinical response in melanoma patients. METHODS: We report a case of vitiligo associated with a novel antisurvivin drug and review the literature to determine the pathogenesis of vitiligo occurring during melanoma treatment. RESULTS: A 78-year-old man with stage IV malignant melanoma developed vitiligo after the first therapeutic cycle of a novel antisurvivin drug. Although his vitiligo remained static, his melanoma continued to progress and he died in 8 months. A review of the literature demonstrates a relationship between vitiligo development and improved clinical response in many melanoma cases treated with immunotherapy; however, the relationship may depend on the type of treatment. CONCLUSIONS: Understanding complex immune responses in vitiliginous skin and melanoma sites is important in order to interpret the development of vitiligo occurring during melanoma treatment.
Authors:
Mayumi Fujita; Whitney A High; Shabnam Asgari; Karl D Lewis; Rene Gonzalez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  48     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-30     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Division of Medical Oncology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80010-7163, USA. mayumi.fujita@ucdenver.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Agents / administration & dosage,  adverse effects*
Humans
Imidazoles / administration & dosage,  adverse effects*
Male
Melanoma / drug therapy*
Microtubule-Associated Proteins / antagonists & inhibitors*
Naphthoquinones / administration & dosage,  adverse effects*
Skin Neoplasms / drug therapy*
Vitiligo / chemically induced*,  pathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/BIRC5 protein, human; 0/Imidazoles; 0/Microtubule-Associated Proteins; 0/Naphthoquinones; 0/YM 155

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