Document Detail


Development and validation of a patient symptom questionnaire to facilitate early diagnosis of thyroid-associated orbitopathy in graves' disease.
MedLine Citation:
PMID:  19085296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To construct a patient-based symptom questionnaire to facilitate early referral of thyroid-associated orbitopathy (TAO) in Graves' hyperthyroidism (GH). METHODS: Phase I of our study involved developing a symptomatology-based questionnaire for the self-reporting of TAO symptoms in patients recently diagnosed with GH. Phase II involved administering the questionnaire along with a standard ophthalmic examination to a screening cohort of patients newly diagnosed with GH. Symptoms highly associated with the clinical diagnosis of TAO were used to construct a tool with the highest possible sensitivity. Phase III involved validation of this tool in a new cohort of patients recently diagnosed with GH. For each patient, the diagnosis of TAO was made by both a standardized orbital ophthalmic exam and the questionnaire. Results from the questionnaire were then compared to the clinical examination. RESULTS: The questionnaire was compared to the standardized examination and found to have a sensitivity of 0.76 and a specificity of 0.82 in the validation phase of the study. INTERPRETATION: This questionnaire may be a useful tool in clinical practice to allow identification of patients with TAO secondary to GH. Future studies using this questionnaire are needed to determine whether earlier identification and management of these patients is associated with reduced morbidity from TAO.
Authors:
Kam Mohaseb; Mark Linder; Jack Rootman; G E Wilkins; Martin T Schechter; Peter J Dolman; Joel Singer
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Orbit (Amsterdam, Netherlands)     Volume:  27     ISSN:  1744-5108     ISO Abbreviation:  Orbit     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-01-30     Revised Date:  2009-02-20    
Medline Journal Info:
Nlm Unique ID:  8301221     Medline TA:  Orbit     Country:  England    
Other Details:
Languages:  eng     Pagination:  419-25     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences and Department of Health Care & Epidemiology, University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Early Diagnosis
False Negative Reactions
Graves Disease / diagnosis
Graves Ophthalmopathy / diagnosis*
Humans
Iodine Radioisotopes
Orbital Diseases / diagnosis*
Predictive Value of Tests
Questionnaires*
Reproducibility of Results
Sensitivity and Specificity
Thyroid Diseases / diagnosis
Thyroid Neoplasms / radionuclide imaging
Thyrotoxicosis / diagnosis
Thyrotropin / blood
Whole Body Imaging
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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