| Development and validation of a method of cilia motility analysis for the early diagnosis of primary ciliary dyskinesia. | |
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MedLine Citation:
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PMID: 21907944 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Primary ciliary dyskinesia (PCD) is a clinically uniform entity, but cilia motility and structure can vary between patients, making the diagnostic difficult. The aim of this study was to evaluate the sensitivity and specificity in diagnosing PCD of a system of high-resolution digital high-speed video analysis with proprietary software that we developed for analysis of ciliary motility (Desinsoft-Bio 200). The secondary aim was to correlate nasal ciliary activity with clinical and structural abnormalities in PCD. MATERIAL AND METHODS: We analysed nasal mucociliary transport, cilia ultrastructure, nasal ciliary beat frequency and beat pattern studied by high-resolution digital high-speed video in 25 cases of PCD (11 Kartagener syndrome), 27 secondary ciliary dyskinesia and 34 healthy volunteers. RESULTS: Nasal mucociliary transport was defective in both primary and secondary ciliary dyskinesia. Ciliary immotility was observed only in 6 patients with Kartagener syndrome and correlated with the absence of dynein. We observed a correlation between partial dynein deficiencies and ciliary dyskinesia. Cilia activity and structure was normal in secondary ciliary dyskinesia. CONCLUSION: Nasal mucociliary transport showed high sensitivity for PCD diagnosis with a low specificity. High-resolution digital high-speed video has a high sensitivity and specificity for diagnosing PCD. This system of video analysis is more useful than ultrastructural study and mucociliary transport for PCD screening. Dynein absence is correlated with cilia immotility and is more common in patients with Kartagener syndrome. |
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Authors:
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Miguel Armengot; Mireya Bonet; Carmen Carda; María José Gómez; Javier Milara; Manuel Mata; Julio Cortijo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-9 |
Journal Detail:
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Title: Acta otorrinolaringologica espanola Volume: - ISSN: 1988-3013 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 14540260R Medline TA: Acta Otorrinolaringol Esp Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier España, S.L. All rights reserved. |
Affiliation:
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Sección de Rinología, Servicio de Otorrinolaringología, Hospital General Universitario, Universidad de Valencia, Valencia, España. |
Vernacular Title:
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Desarrollo y validación de un método de análisis de la movilidad ciliar para el diagnóstico precoz de la discinesia ciliar primaria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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