| Development and validation of a limited sampling strategy for 5-fluorouracil given by bolus intravenous administration. | |
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MedLine Citation:
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PMID: 8249045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A wide range of interindividual variability of 5-fluorouracil (5-FU) pharmacokinetics exists after bolus administration. The degree to which this variability in 5-FU exposure impacts upon the response and toxicity of the drug has not been determined. The area under the concentration time curve (AUC) is a commonly used indicator of exposure, but normally requires the collection of 8-10 timed blood samples after i.v. bolus administration. This presents difficulties if large-scale population samplings are required. This study involved the development and testing of a strategy to estimate AUC from a limited number of blood samples in patients with gastrointestinal and breast cancer. The optimal single time point for AUC estimation was 0.17 h (r2 = 0.954). Addition of the 0.75 h time point significantly improved predictability (r2 = 0.983). Addition of a third or fourth time point did not provide further benefit. These models were then tested separately in a group of women who received a higher dose of 5-FU. The two data points model performed significantly better than the single time point model (r2 = 0.70 and 0.85, respectively). The AUC of standard dose 5-FU after bolus administration can be reliably estimated from two timed samples taken 10 and 45 min after injection. |
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Authors:
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M J Moore; P Bunting; S Yuan; J J Thiessen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 15 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-06 Completed Date: 1994-01-06 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 394-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Princess Margaret Hospital, University of Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Breast Neoplasms / blood, drug therapy Chemotherapy, Adjuvant Cyclophosphamide / administration & dosage Female Fluorouracil / administration & dosage, blood, pharmacokinetics* Humans Injections, Intravenous Methotrexate / administration & dosage Middle Aged Models, Biological* Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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