| Development of type 1 diabetes mellitus in nonobese diabetic mice follows changes in thymocyte and peripheral T lymphocyte transcriptional activity. | |
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MedLine Citation:
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PMID: 21765850 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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As early as one month of age, nonobese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, producing autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothesized that during the development of T1D, the transcriptional modulation of immune reactivity genes may occur as thymocytes mature into peripheral T lymphocytes. The transcriptome of thymocytes and peripheral CD3(+) T lymphocytes from prediabetic or diabetic mice analyzed through microarray hybridizations identified 2,771 differentially expressed genes. Hierarchical clustering grouped mice according to age/T1D onset and genes according to their transcription profiling. The transcriptional activity of thymocytes developing into peripheral T lymphocytes revealed sequential participation of genes involved with CD4(+)/CD8(+) T-cell differentiation (Themis), tolerance induction by Tregs (Foxp3), and apoptosis (Fasl) soon after T-cell activation (IL4), while the emergence of T1D coincided with the expression of cytotoxicity (Crtam) and inflammatory response genes (Tlr) by peripheral T lymphocytes. |
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Authors:
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Thais A Fornari; Paula B Donate; Claudia Macedo; Elza T Sakamoto-Hojo; Eduardo A Donadi; Geraldo A Passos |
Publication Detail:
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Type: Journal Article Date: 2011-06-15 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2011 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: Egypt |
Other Details:
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Languages: eng Pagination: 158735 Citation Subset: IM |
Affiliation:
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Molecular Immunogenetics Group, Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), 14040-900, School Ribeirão Preto, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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