Document Detail

Development of tumors in the glandular stomach of rats after oral administration of carcinogens. II. Different cell types in antral carcinoma as revealed by electron microscopy.
MedLine Citation:
PMID:  136829     Owner:  NLM     Status:  MEDLINE    
In the present study electron microscopic investigations of tumors of the glandular stomach of rats induced by oral administration of MNNG or ENNG are dealt with. The aim of the study was to describe the different cell types found in the carcinoma and to elucidate the possible relationship between the undifferentiated carcinoma cells and the more differentiated cell types found in the tumor. The results show that besides undifferentiaded carcinoma cells, several differentiated cell types such as goblet cells, endocrine cells, cells with lamellated inclusions in their cytoplasm, and squamous carcinoma cells can be observed. The most conspicuous findings were carcinomatous gland cells with well differentiated microvilli on their luminal surface and typical tonofilamentous structures in their cytoplasm. These cells exhibited signs of the squamous epithelium and of gland cells. Therefore they may be considered as intermediate variants between adenocarcinoma cells and squamous carcinoma cells. The occurrence of such intermediate steps points to the possibility of differentiation by cell division of adenocarcinoma cells into several metaplastic cell types in the experimental stomach carcinoma induced by MNNG or ENNG.
Y Uchida; A Roessner; W Schlake; D Rühland; H Themann; E Grundmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology     Volume:  87     ISSN:  0084-5353     ISO Abbreviation:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  1276653     Medline TA:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  213-28     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / ultrastructure
Carcinoma, Squamous Cell / ultrastructure
Cell Differentiation
Intestinal Mucosa
Microscopy, Electron
Neoplasms, Experimental
Pyloric Antrum
Stomach Neoplasms / chemically induced*,  ultrastructure
Reg. No./Substance:

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