Document Detail


Development of a toxin screening multi-parameter on-line biochip system 'Toxichip'.
MedLine Citation:
PMID:  21096758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of a cell based biochip-sensing platform that examines the effects of toxic chemicals both electrically and optically is presented. The name of this sensing platform is called Toxichip. Toxichip aims to develop and promote alternative novel in-vitro testing methods for the monitoring of a vast array of toxins, thus alleviating the current demand for animal sacrifice while also permitting high throughput screening. Cell-based biosensors (CBBs), which treat living cells as sensing elements, are able to detect the functional information of biologically active analytes and also provide quantitative analysis. In general, they maintain living cells and observe the cellular physiological response after subjecting cells to toxin stimuli and verify the presence and the concentration of these stimuli. CBBs characterise with high sensitivity, excellent selectivity and a fast response time. There has been increased interest in the use of microelectronic biosensors that allow cellular activity to be analysed in vitro.
Authors:
Eric Moore
Related Documents :
2986318 - Enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: i...
7190848 - Stimulation of cell surface phospholipase a2 and prostaglandin synthesis in 3t2 mouse f...
8069588 - Selective targeting of malignant cells with cytotoxin-folate conjugates.
17313178 - Peculiar binding of botulinum neurotoxins.
3375428 - Split-dose recovery and protein synthesis in x-irradiated cho cells.
6303428 - Properties of multiple kinetic forms of soluble cyclic nucleotide phosphodiesterase act...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-25     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biosensing Techniques / methods*
Cell Culture Techniques / methods
Cell Line, Tumor
Humans
Tissue Array Analysis / instrumentation*,  methods*
Toxicology / instrumentation*,  methods*
Toxins, Biological / isolation & purification*
Chemical
Reg. No./Substance:
0/Toxins, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Monolithically integrated biosensors based on Frequency-Resolved Mach-Zehnder Interferometers for mu...
Next Document:  Microfluidic and transducer technologies for lab on a chip applications.