Document Detail

Development of tobacco smoke-induced lung tumors in mice fed Bowman-Birk protease inhibitor concentrate (BBIC).
MedLine Citation:
PMID:  12065088     Owner:  NLM     Status:  MEDLINE    
Male strain A/J mice were exposed, 6h a day, 5 days a week for 5 months to a mixture of 89% cigarette sidestream and 11% cigarette mainstream smoke and then allowed to recover for another 4 months in air. The animals were fed Bowman-Birk protease inhibitor concentrate (BBIC) at a concentration of 1% in AIN-93G diet either during smoke exposure, following smoke exposure or during the entire 9 months. At the end of the experiment, the incidence and multiplicity of lung tumors were determined. In a positive control experiment, strain A/J mice were injected with 3-methylcholanthrene (MCA) and fed a diet containing 1% BBIC; these animals were killed 5 months later. It was found that in the animals treated with MCA, BBIC decreased lung tumor multiplicities, whereas in the smoke exposed mice, BBIC did not modulate lung tumor development.
Hanspeter Witschi; Imelda Espiritu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  183     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA.
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MeSH Terms
Body Weight / drug effects
Lung Neoplasms / chemically induced*,  pathology*,  prevention & control
Time Factors
Tobacco / adverse effects*
Trypsin Inhibitor, Bowman-Birk Soybean / therapeutic use*
Trypsin Inhibitors / therapeutic use
Grant Support
Reg. No./Substance:
0/Carcinogens; 0/Trypsin Inhibitor, Bowman-Birk Soybean; 0/Trypsin Inhibitors; 56-49-5/Methylcholanthrene

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