| Development of a theoretical model describing sonoporation activity of cells exposed to ultrasound in the presence of contrast agents. | |
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MedLine Citation:
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PMID: 22501051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sonoporation uses ultrasound, with the aid of ultrasound contrast agents (UCAs), to enhance cell permeabilization, thereby allowing delivery of therapeutic compounds noninvasively into specific target cells. The objective of this study was to determine if a computational model describing shear stress on a cell membrane due to microstreaming would successfully reflect sonoporation activity with respect to the peak rarefactional pressure. The theoretical models were compared to the sonoporation results from Chinese hamster ovary cells using Definity(®) at 0.9, 3.15, and 5.6 MHz and were found to accurately describe the maximum sonoporation activity, the pressure where a decrease in sonoporation activity occurs, and relative differences between maximum activity and the activity after that decrease. Therefore, the model supports the experimental findings that shear stress on cell membranes secondary to oscillating UCAs results in sonoporation. |
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Authors:
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Monica M Forbes; William D O'Brien |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 131 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-16 Completed Date: 2012-06-28 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 2723-9 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N Mathews, Urbana, Illinois 61801, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CHO Cells Cell Membrane Permeability / drug effects*, physiology Contrast Media / pharmacology* Cricetinae Cricetulus Microbubbles Models, Biological* Sonication / methods Ultrasonics* |
| Grant Support | |
ID/Acronym/Agency:
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F31EB06634/EB/NIBIB NIH HHS; R37 EB002641/EB/NIBIB NIH HHS; R37EB02641/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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