Document Detail


Development of a theoretical model describing sonoporation activity of cells exposed to ultrasound in the presence of contrast agents.
MedLine Citation:
PMID:  22501051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sonoporation uses ultrasound, with the aid of ultrasound contrast agents (UCAs), to enhance cell permeabilization, thereby allowing delivery of therapeutic compounds noninvasively into specific target cells. The objective of this study was to determine if a computational model describing shear stress on a cell membrane due to microstreaming would successfully reflect sonoporation activity with respect to the peak rarefactional pressure. The theoretical models were compared to the sonoporation results from Chinese hamster ovary cells using Definity(®) at 0.9, 3.15, and 5.6 MHz and were found to accurately describe the maximum sonoporation activity, the pressure where a decrease in sonoporation activity occurs, and relative differences between maximum activity and the activity after that decrease. Therefore, the model supports the experimental findings that shear stress on cell membranes secondary to oscillating UCAs results in sonoporation.
Authors:
Monica M Forbes; William D O'Brien
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  131     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2723-9     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N Mathews, Urbana, Illinois 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells
Cell Membrane Permeability / drug effects*,  physiology
Contrast Media / pharmacology*
Cricetinae
Cricetulus
Microbubbles
Models, Biological*
Sonication / methods
Ultrasonics*
Grant Support
ID/Acronym/Agency:
F31EB06634/EB/NIBIB NIH HHS; R37 EB002641/EB/NIBIB NIH HHS; R37EB02641/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media
Comments/Corrections

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