Development of a swine animal model for the study of sudden infant death syndrome. | |
MedLine Citation:
|
PMID: 7474879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An animal model with selective cardiac autonomic denervation was developed in neonatal swine for the purpose of future studies concerning the possible role of abnormal cardiac innervation in the etiology of sudden infant death syndrome. Twenty-six 4- to 8-day old piglets were randomly assigned to one of the following treatment groups: right stellate ganglionectomy (RSG), left stellate ganglionectomy (LSG), right cardiac vagotomy (RCV), and sham-operated control group. Piglets were anesthetized with Saffan and mechanically ventilated on room air. The thoracic wall was opened, and the sternum was divided, permitting exposure of pleura, heart, and lungs. After completion of one of these operative procedures, the thoracic wall was closed in layers. On successful recovery from anesthesia and extubation, piglets were returned to their sows. Postoperative administration of antibiotics was performed during the first week. Electrocardiograms were recorded once a week over an 8-week period. The sham-operated control group had a postnatal increase in QTc and decrease in heart rate. The RSG group had significantly longer QTc than the sham-operated control group QTc, whereas the RCV group had significantly shorter QTc interval than sham-operated controls. Surgical complications caused the death of two piglets (hemorrhage in one and aspiration in the other), infection caused the death of one piglet 2 weeks after surgery, and three died of unknown causes (one from the RSG group and two from the RCV group). The cause of death for these three animals could not be determined (necropsy was not revealing) because they were not monitored at the time of their demise.(ABSTRACT TRUNCATED AT 250 WORDS) |
Authors:
|
S Tong; S Ingenito; J E Anderson; N Gootman; A L Sica; P M Gootman |
Related Documents
:
|
19932239 - 12-month outcome after cardiac surgery: prediction by troponin t in combination with th... 9618809 - Mediastinitis without antecedent surgery. 24274639 - Mean platelet volume as a potential prognostic marker in patients with acute mesenteric... 1273099 - Physical therapy program for the pediatric cardiac surgical patient. 19085899 - Quantitative evaluation of the systemic effects of transposed basilic vein to brachial ... 19538229 - Midterm results of passive containment surgery using the acorn cor cap cardiac support ... 17962909 - Combined lensectomy, vitrectomy, and primary intraocular lens implantation in patients ... 12015719 - Influence of steroids and methotrexate on wound complications after elective rheumatoid... 21730279 - Tigecycline for the treatment of severe clostridium difficile infection (july/august). |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Laboratory animal science Volume: 45 ISSN: 0023-6764 ISO Abbreviation: Lab. Anim. Sci. Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-12-07 Completed Date: 1995-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 1266503 Medline TA: Lab Anim Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 398-403 Citation Subset: IM |
Affiliation:
|
Department of Physiology, State University of New York Health Science Center at Brooklyn 11203, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
Alfaxalone Alfadolone Mixture Anesthesia Animals Animals, Newborn* Autonomic Nervous System Denervation Disease Models, Animal* Electrocardiography Ganglionectomy Heart / innervation, physiopathology Heart Rate Humans Infant Stellate Ganglion / surgery Sudden Infant Death* / etiology Swine* Vagotomy |
Grant Support | |
ID/Acronym/Agency:
|
HD-28931/HD/NICHD NIH HHS |
Chemical | |
Reg. No./Substance:
|
8067-82-1/Alfaxalone Alfadolone Mixture |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of a rat model for iron deficiency and toxicological studies: comparison among Fischer 3...
Next Document: Use of surgical intrauterine insemination to manage infertility in a colony of research German sheph...