Document Detail

Development of the surfactant system.
MedLine Citation:
PMID:  7547365     Owner:  NLM     Status:  MEDLINE    
Pulmonary surfactant is a lipoprotein complex produced by type II pneumocytes that lines and stabilizes alveoli. Surfactant-specific proteins are early markers of the embryonic lung. Precursors of type II pneumocytes appear to be committed early and are able to pursue their differentiation program in a relatively autonomous way. Despite this potential, surfactant ontogeny and storage actually take place relatively late in the course of fetal development. Surfactant accumulation is, therefore, delayed until a certain stage after which it is stimulated by a number of factors. Recent investigations have pointed out the possible role of paracrine mechanisms in the determinism of this control, especially with regard to retinoids and TGF-beta.
J R Bourbon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology. Supplement     Volume:  11     ISSN:  1054-187X     ISO Abbreviation:  Pediatr Pulmonol Suppl     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-08     Completed Date:  1995-11-08     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  9014095     Medline TA:  Pediatr Pulmonol Suppl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-5     Citation Subset:  IM    
INSERM U 319, Université Denis Diderot-Paris 7, France.
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MeSH Terms
Embryonic and Fetal Development
Fetal Organ Maturity / physiology
Lung / embryology*,  metabolism
Pulmonary Surfactants / biosynthesis*
Reg. No./Substance:
0/Pulmonary Surfactants

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