| Development of subacute cutaneous lupus erythematosus associated with the use of imiquimod to treat actinic keratoses. | |
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MedLine Citation:
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PMID: 20684157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunomodulating drug imiquimod is approved by the U.S. Food and Drug Administration (FDA) to treat actinic keratoses, non-facial superficial basal cell carcinomas and genital warts. This drug elicits its immunological response by binding to toll-like receptor 7 (TLR-7) on dendritic cells inducing the production of interferon alpha (IFN-alpha) and other inflammatory cytokines. The authors report the case of a 56-year-old female who developed subacute cutaneous lupus erythematosus (SCLE), as well as severe autoimmune retinitis following a vigorous response to imiquimod 5% cream that was prescribed to treat actinic keratoses. Given the important role of IFN-alpha in the pathogenesis of cutaneous lupus, it is likely that imiquimod either induced or unmasked an autoimmune tendency in this patient. |
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Authors:
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Thomas J Burnett; Joseph C English; Laura Korb Ferris |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 9 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1022-4 Citation Subset: IM |
Affiliation:
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United States Air Force, WPAFB, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage,
adverse effects*,
therapeutic use Administration, Cutaneous Aminoquinolines / administration & dosage, adverse effects*, therapeutic use Autoimmune Diseases / chemically induced Female Humans Keratosis, Actinic / drug therapy Lupus Erythematosus, Cutaneous / chemically induced* Middle Aged Retinitis / chemically induced, immunology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Aminoquinolines; 99011-02-6/imiquimod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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