Document Detail


Development, structure and function of the cranial suspensory ligaments of the mammalian gonads in a cross-species perspective; their possible role in effecting disturbed testicular descent.
MedLine Citation:
PMID:  15717439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present review aims to present a perspectiveon a relatively unknown part of the mammalian internal genitalia: their cranial suspensory apparatus. This apparatus shows wide divergence of development when examined during the fetal period or during adulthood, in males or females, or in individuals across a variety of species. In rats and other mamalian species the apparatus undergoes a distinct patern of sexually dimorphic development and fetal testicular androgens are proposed to play a key role in this process. Extensive development of this suspensory apparatus in females is argued to be a part of the anatomical adaptations of the genital apparatus to support the internal genitalia throughout pregnancy, including the relatively enormous growth towards the time of parturition. Minor development of this apparatus in males is judged to be a part of the anatomical requirements allowing developing testes to become displaced from the dorsal abdominal wall during the first stage of testicular descent. Extensive development of this suspensory apparatus in males generally seems to hinder testicular descent. Accordingly, the apparatus is well developed in so-called testicond species which do not show testis descent as a part of their normal male genital development. Furthermore, arguments are adduced that inappropriate and extensive development in species with testis descent may be a key aetiological factor in the disturbance of this process. Diagnosis and treatment of human cryptorchidism might profit from including an analysis of the development and function of (remnants of) the cranial testicular and epididymal suspensory apparatus.
Authors:
P van der Schoot; J M Emmen
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  2     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  2005-02-18     Completed Date:  2005-03-11     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-418     Citation Subset:  IM    
Affiliation:
Department of Endocrinology & Reproduction, Erasmus University Rotterdam, Faculty of Medicine and Health Sciences, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Androgens / physiology
Animals
Cattle
Cryptorchidism / embryology,  etiology*
Female
Genitalia / embryology,  growth & development*
Genitalia, Female / embryology,  growth & development
Genitalia, Male / embryology,  growth & development
Humans
Ligaments / embryology,  growth & development*
Male
Mice
Models, Biological
Rats
Sex Characteristics
Species Specificity
Chemical
Reg. No./Substance:
0/Androgens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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