| Development status of Terumo implantable left ventricular assist system. | |
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MedLine Citation:
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PMID: 11403674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have been developing an implantable left ventricular assist system (T-ILVAS) featuring a magnetically suspended centrifugal pump (MSCP) since 1995. In vitro and in vivo studies using a prototype MSCP composed of a polycarbonate housing and impeller (196 ml) have demonstrated long-term durability and excellent blood compatibility for up to 864 days, and excellent stability of the magnetic bearing of the MSCP. These preliminary results strongly suggested that the magnetic bearing of the MSCP is reliable and is a most feasible mechanism for a long-term circulatory assist device. We have recently devised a clinical version pump made of titanium (180 ml) with a new position sensor mechanism and a wearable controller with batteries. Cadaver fit study confirmed that the Type IV pump could be implanted in a small patient with a body surface area as small as 1.3. The in vitro performance tests of the Type IV pump demonstrated excellent hydrodynamic performances with an acceptable hemolysis rate. New position sensors for the titanium housing showed more uniform sensor outputs of a magnetic bearing than in the prototype polycarbonate pump. The Type IV pump then was evaluated in vivo in 6 sheep at the Oxford Heart Centre. Four sheep were electively sacrificed at 3 months and were allowed to survive for more than 6 months for long-term evaluation. In this particular series of experiments, no anticoagulant/antiplatelet regimen was utilized except for a bolus dose of heparin during surgery. There was a left ventricular mural thrombi around the inflow cannula in 1 sheep. Otherwise, there was no mechanical failure nor sign of thromboembolism throughout the study. |
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Authors:
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C Nojiri; T Kijima; J Maekawa; K Horiuchi; T Kido; T Sugiyama; T Mori; N Sugiura; T Asada; W Umemura; T Ozaki; M Suzuki; T Akamatsu; S Westaby; T Katsumata; S Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial organs Volume: 25 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-07-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 411-3 Citation Subset: IM |
Affiliation:
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Terumo Corporation, Research and Development Center, Ann Arbor, Michigan, USA. chico@mb.infoweb.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart-Assist Devices* Implants, Experimental Magnetics Prosthesis Design* Sheep Titanium |
| Chemical | |
Reg. No./Substance:
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7440-32-6/Titanium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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