| Development of a standardized animal model for the study of alkali ingestion. | |
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MedLine Citation:
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PMID: 11824779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to develop an animal model that would grade in-vivo therapeutic modality testing for caustic ingestion. Caustic substances are found in many household items (eg detergents, bleaches, pipe cleaners) and pose a serious threat to health if ingested accidentally or intentionally with resulting injuries including immediate death or chronic debilitating morbidity. This study used 5, 3.8 or 1.8% sodium hydroxide (NaOH) to determine macro/microscopic injury at 10, 30, or 60 minutes. Macroscopic grading was based on gross evaluation of denudation of mucosa, edema, hyperemia, hemorrhage, ulcerations and necrosis. Microscopic grading was based on epithelial viability, cornified epithelial cell differentiation, granular cell differentiation, epithelial cell nuclei, muscle cell viability and muscle cell nuclei. Product concentration was shown a more significant predictor of injury than time of exposure. The grading system presented should provide a reliable method of producing and grading alkaline ingestions for future treatment hypothesis testing. |
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Authors:
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Jerry R Baskerville; Ronald E Nelson; Timothy L Reynolds; Michael Cohen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary and human toxicology Volume: 44 ISSN: 0145-6296 ISO Abbreviation: Vet Hum Toxicol Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-04 Completed Date: 2002-07-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7704194 Medline TA: Vet Hum Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 45-7 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Scott & White Clinic and Memorial Hospital, Texas A&M University Health Science Center, College of Medicine, Temple 76508, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Caustics / administration & dosage, toxicity* Dose-Response Relationship, Drug Esophagus / drug effects*, pathology Lye / administration & dosage, toxicity* Male Models, Animal Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Caustics; 0/Lye |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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