Document Detail

Development of the semi-synthetic penicillins and cephalosporins.
MedLine Citation:
PMID:  18248798     Owner:  NLM     Status:  MEDLINE    
Semi-synthetic penicillins and cephalosporins both derive from their respective chemical nuclei, 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA). Work leading to their isolation was being carried out in parallel, but following very different pathways, during the last half of the 1950s. The development of 6-APA was reviewed recently in this journal, and in the present article I take a closer look at early work on 'penicillin amidase' and revisit the steps that led to 7-ACA.
J M T Hamilton-Miller
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2008-01-08
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  31     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Department of Medical Microbiology, Royal Free and University College Medical School, London, UK.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis*,  history*
Cephalosporins / chemical synthesis*,  history*
History, 19th Century
Penicillins / chemical synthesis*,  history*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Penicillins

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