Document Detail


Development of selected coagulation factors and anticoagulants in preterm infants by the age of six months.
MedLine Citation:
PMID:  15467897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of the coagulation and anticoagulation system in preterm infants was assessed, with special emphasis on extremely low birth weight (ELBW) infants and haemorrhagic or other complications after birth. Coagulation factors II (prothrombin), V (FV), VII (FVII) and X (FX) were analysed at birth and at a corrected age of six months. In addition, antithrombin (AT), protein C (PC) and protein S (PS) were measured at six months, and DNA samples were tested for Factor V Leiden (R506Q). Eighty-two infants, with a median gestational age (GA) of 32 weeks (range 24-36) and a median birth weight of 1562 g (range 695-3520), were studied. Fifteen of these were ELBW infants (range 695-1000g). Prothrombin, FV, FVII and FX reached healthy term six-month-old infant activity levels. Prothrombin and FX did not reach adult values; median activity levels remained at 82% and 78%, respectively. During the follow up, the FV and FVII levels of the ELBW infants (GA 24-27 weeks) increased more than those of the preterm infants born with higher GA (p < 0.001). At birth, prothrombin correlated significantly with FV, FVII and FX (p < 0.001). FVII at birth and at six months correlated significantly with PC (p = 0.021 and p = 0.009, respectively). These findings indicate that the gain in the coagulation factor concentrations in infancy is greatest in infants with the lowest GA at birth. Interesting new inter-relations of coagulation factor and physiological anticoagulant levels may indicate that there are still unrecognised pathways in the function of newborn haemostasis.
Authors:
Marjut Salonvaara; Pekka Riikonen; Elina Vahtera; Eija Mahlamäki; Kirsti Heinonen; Riitta Kekomäki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  92     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  688-96     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Kuopio University Hospital, P.O.B. 1777, FIN- 70211, Kuopio, Finland. marjut.salonvaara@fimnet.fi
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Blood Coagulation Factor Inhibitors / analysis*,  physiology
Blood Coagulation Factors / analysis*,  physiology
Female
Gestational Age
Hemostasis
Humans
Infant
Infant, Newborn
Infant, Premature / blood*
Male
Chemical
Reg. No./Substance:
0/Blood Coagulation Factor Inhibitors; 0/Blood Coagulation Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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