| Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. | |
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MedLine Citation:
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PMID: 21867724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Electrophysiological and pharmacological studies coupled with molecular identification have revealed a unique network of ion channels-Kv1.3, KCa3.1, CRAC (Orai1 + Stim1), TRPM7, Cl(swell)-in lymphocytes that initiates and maintains the calcium signaling cascade required for activation. The expression pattern of these channels changes during lymphocyte activation and differentiation, allowing the functional network to adapt during an immune response. The Kv1.3 channel is of interest because it plays a critical role in subsets of T and B lymphocytes implicated in autoimmune disorders. The ShK toxin from the sea anemone Stichodactyla helianthus is a potent blocker of Kv1.3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011. This review describes the journey that has led to the development of ShK-186. |
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Authors:
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Victor Chi; Michael W Pennington; Raymond S Norton; Eric Tarcha; Luz Londono; Brian Sims-Fahey; Sanjeev K Upadhyay; Jonathan T Lakey; Shawn Iadonato; Heike Wulff; Christine Beeton; K George Chandy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: - ISSN: 1879-3150 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Physiology and Biophysics, UC Irvine, Irvine, CA 92697, USA; Department of Surgery, UC Irvine, Irvine, CA 92697, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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