| Development of sarcoidosis in etanercept-treated rheumatoid arthritis patients. | |
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MedLine Citation:
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PMID: 17340045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report two rheumatoid arthritis patients developing sarcoidosis possibly induced by etanercept. Both women, aged 46 and 53, had erosive, rheumatoid-factor-positive rheumatoid arthritis (RA) for 7 and 6 years, respectively. The eldest had received infliximab for over a year with good response, which was stopped because of a perfusion reaction. She developed a cough and dyspnea after 6 months of etanercept treatment. The other developed erythema nodosum and a plaque lesion on the right arm after 1 year of etanercept. Imaging showed, in both cases, mediastinal adenopathies. Biopsies were compatible with sarcoidosis. Etanercept withdrawal led to a complete remission. Recently, there have been reports of noninfectious granulomatous syndromes in patients receiving etanercept for a variety of diseases. In our cases, the temporal association with etanercept therapy and the complete remission after suspension of etanercept suggest a triggering role of this agent. Possible mechanisms of action and supporting evidence are discussed. |
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Authors:
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Kilian Verschueren; Els Van Essche; Patrick Verschueren; Veerle Taelman; Rene Westhovens |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-06 |
Journal Detail:
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Title: Clinical rheumatology Volume: 26 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
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Languages: eng Pagination: 1969-71 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium. rene.westhovens@uz.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects Antirheumatic Agents / adverse effects* Arthritis, Rheumatoid / complications*, drug therapy* Biopsy Comorbidity Female Humans Immunoglobulin G / adverse effects* Middle Aged Receptors, Tumor Necrosis Factor Remission Induction Sarcoidosis / chemically induced*, diagnosis* Treatment Outcome Tumor Necrosis Factor-alpha / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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