| Development and reversal of contingent inefficacy and tolerance to the anticonvulsant effects of carbamazepine. | |
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MedLine Citation:
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PMID: 1985824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship of the timing of drug administration to anticonvulsant efficacy against amygdala kindled seizures was studied. During kindling development, rats received carbamazepine (CBZ, 15mg/kg) before (CBZ-before) or after each amygdala stimulation (CBZ-after). After kindling to full seizures, when all animals were given CBZ before the stimulation, only the CBZ-after group showed a good anticonvulsant response. The rats that had received CBZ before (during development of kindled seizures) remained unresponsive to CBZ treatment (contingent inefficacy). When drug-naive or CBZ-after animals repeatedly received CBZ before electrical stimulation, they developed tolerance to its anticonvulsant effects (contingent tolerance). The tolerance could be reversed by a period of treatment with CBZ-after or by kindling the animal drug-free, but not by CBZ administration alone or by time off from both drug and seizures. These findings suggest that inefficacy and tolerance to CBZ may be affected by the temporal contingencies of drug administration and that responsiveness can be reinstated by altering these contingencies. |
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Authors:
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S R Weiss; R M Post |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 32 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1991 Jan-Feb |
Date Detail:
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Created Date: 1991-02-11 Completed Date: 1991-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM |
Affiliation:
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Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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drug effects,
physiology* Animals Carbamazepine / administration & dosage, pharmacology* Drug Tolerance Electric Stimulation Injections, Intraperitoneal Kindling, Neurologic / drug effects*, physiology Male Models, Neurological Rats Rats, Inbred Strains Seizures / etiology, prevention & control* Time Factors |
| Chemical | |
Reg. No./Substance:
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298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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