Document Detail


Development of retinal projections and response to photic input in the suprachiasmatic nucleus of New Zealand White Rabbits.
MedLine Citation:
PMID:  23313583     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In rabbit pups, nursing by the mother is the prevailing entraining signal for their circadian rhythms during at least the first two weeks of life. Therefore, they are considered a natural model of food anticipatory activity. However, the photic entrainment of the circadian system in rabbit pups during this developmental stage is not well understood. The present study examined the retinal projections to the suprachiasmatic nucleus (SCN) and the functional responses of the SCN to light exposure. Using the anterograde tracer cholera toxin-B, we examined the retinal projections to the SCN at postnatal days (PD) 1, 9, 19 and in adult animals. The results revealed that the retinal projections were present at PD1 with a bilateral symmetry, and with a contralateral tendency at PD19 and adults. We also explored the response of the SCN to a light pulse by assessing the induction of FOS protein, a marker of neuronal activation, at PD1, 12, 19 and in adults. Light-induced FOS was observed during day and night at PD1, but mainly during night at PD12, 19 and adults. We conclude that in the SCN there is a "gating" mechanism to FOS induction by light that develops several days after birth, as in other mammals, and in the rabbit is already present at PD12. Moreover, in contrast to other altricial mammals, the circadian visual system, although not essential for entraining the rhythm during first two weeks of life, is present and functional in rabbit pups from birth.
Authors:
Claudia Juárez; Elvira Morgado; Enrique Meza; Stefan M Waliszewski; Raúl Aguilar-Roblero; Mario Caba
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Brain research     Volume:  -     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Ver., México.
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