Document Detail


Development of resistance to biologic therapies with reference to IFN-β: Understanding drug resistance to biological therapy.
MedLine Citation:
PMID:  22258390     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
All biotherapeutics have the potential to generate anti-drug antibodies (ADAs) in patients. The main factors leading to an immune response are thought to be product, treatment and patient related. In this review, reasons for the formation of ADAs, and particularly neutralizing antibodies (NAbs), are considered, with a focus on IFN-β as a well-studied example. The time course for the production of NAbs, the measurement of NAbs, the defining of IFN-β responders and non-responders, the implications for disease progression in patients, and future methods for avoiding the production of ADAs and of tolerizing patients are considered.
Authors:
Rachel A Farrell; Monica Marta; Adriana J Gaeguta; Veronika Souslova; Gavin Giovannoni; Paul I Creeke
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  -     ISSN:  1462-0332     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neuroinflammation, UCL Institute of Neurology, Department of Therapies and Rehabilitation, National Hospital of Neurology and Neurosurgery and Neuroimmunology Unit, Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK.
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