Document Detail

Development of resistance to activated protein C during pregnancy.
MedLine Citation:
PMID:  7647019     Owner:  NLM     Status:  MEDLINE    
We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14-20, 28 and 36 weeks gestation, and at 1 d post-partum. Significant reductions in the mean APC sensitivity ratio (APC-SR) were observed at all stages of pregnancy studied compared with the mean APC-SR obtained for baseline measurements carried out at > 8 weeks post-partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14-20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.
A M Cumming; R C Tait; S Fildes; A Yoong; S Keeney; C R Hay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  90     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  725-7     Citation Subset:  IM    
University Department of Haematology, Manchester Royal Infirmary.
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MeSH Terms
Blood Coagulation
Factor V / genetics
Factor VIII / analysis
Point Mutation
Pregnancy / metabolism*
Pregnancy Complications, Hematologic / etiology
Protein C / metabolism*
Risk Factors
Sensitivity and Specificity
Thrombosis / etiology
Reg. No./Substance:
0/Protein C; 9001-24-5/Factor V; 9001-27-8/Factor VIII

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