| Development of resistance to activated protein C during pregnancy. | |
MedLine Citation:
|
PMID: 7647019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We measured activated protein C (APC) anticoagulant activity in 20 healthy women at 14-20, 28 and 36 weeks gestation, and at 1 d post-partum. Significant reductions in the mean APC sensitivity ratio (APC-SR) were observed at all stages of pregnancy studied compared with the mean APC-SR obtained for baseline measurements carried out at > 8 weeks post-partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14-20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy. |
Authors:
|
A M Cumming; R C Tait; S Fildes; A Yoong; S Keeney; C R Hay |
Related Documents
:
|
10687959 - Presence of uterine peroxidase activity in the rat early pregnancy. 22460969 - Premature delivery in hiv-infected women starting protease inhibitor therapy during pre... 15104609 - Relation of anp and bnp to their n-terminal fragments in fetal circulation: evidence fo... 24650349 - Social support communication in unplanned pregnancy: support types, messages, sources, ... 19936969 - Complement activation and pregnancy failure. 15383399 - Renal epoxyeicosatrienoic acid synthesis during pregnancy. 21985759 - Does light alcohol consumption during pregnancy improve offspring's cognitive development? 11578609 - Fetal and adolescent nicotine administration: effects on cns serotonergic systems. 19022799 - Limitations of adamts-13 activity level in diagnosing thrombotic thrombocytopenic purpu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of haematology Volume: 90 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1995 Jul |
Date Detail:
|
Created Date: 1995-09-25 Completed Date: 1995-09-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 725-7 Citation Subset: IM |
Affiliation:
|
University Department of Haematology, Manchester Royal Infirmary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Coagulation Factor V / genetics Factor VIII / analysis Female Humans Point Mutation Pregnancy / metabolism* Pregnancy Complications, Hematologic / etiology Protein C / metabolism* Risk Factors Sensitivity and Specificity Thrombosis / etiology |
| Chemical | |
Reg. No./Substance:
|
0/Protein C; 9001-24-5/Factor V; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo.
Next Document: Pharmacology of the potassium channel openers.