| Development of reflux esophagitis following Helicobacter pylori eradication. | |
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MedLine Citation:
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PMID: 16322945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We aimed to determine the incidence and causative factors of reflux esophagitis following Helicobacter pylori eradication in Japanese patients. METHODS: In patients in whom reflux esophagitis could not be detected endoscopically, we conducted an annual follow-up observation in 326 H. pylori-cured patients, 199 H. pylori-positive patients, and 151 H. pylori-negative patients, to study the incidence and causative factors of reflux esophagitis. RESULTS: Development of reflux esophagitis was observed in 74 (22.7%) of the H. pylori-cured patients during a median follow-up period of 6.0 years, in 16 (8.0%) of the H. pylori-positive patients during a median follow-up period of 5.0 years, and in 29 (19.2%) of the H. pylori-negative patients during a median follow-up period of 5.4 years. The results, after correction for sex and age, showed that H. pylori-cured patients had a significantly higher risk of reflux esophagitis than H. pylori-positive patients (risk ratio, 2.43; P < 0.01), but their risk did not differ from that in the H. pylori-negative patients. It was also shown that hiatal hernia (risk ratio, 4.01; P < 0.01) and smoking history (risk ratio, 1.77; P < 0.05) were significant risk factors for the development of reflux esophagitis. CONCLUSIONS: With regard to the development of reflux esophagitis following H. pylori eradiation therapy, we observed that the frequency was higher in H. pylori-cured patients than in H. pylori-positive patients, but the frequency in H. pylori-cured patients and H. pylori-negative patients was the same. We elucidated that hiatal hernia and smoking history are important risk factors for reflux esophagitis. |
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Authors:
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Masahiro Kawanishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology Volume: 40 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-12-02 Completed Date: 2006-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
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Languages: eng Pagination: 1024-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Hiroshima Mitsubishi Hospital, 4-6-20 Kannonshin-machi, Nishi-ku, Hiroshima 733-0036, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Esophagitis, Peptic
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diagnosis*,
etiology Esophagoscopy Female Gastroscopy Helicobacter Infections / complications, drug therapy* Helicobacter pylori* Hernia, Hiatal / complications Humans Male Middle Aged Risk Factors Smoking / adverse effects |
| Comments/Corrections | |
Comment In:
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J Gastroenterol. 2005 Nov;40(11):1080-2
[PMID:
16322957
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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