Document Detail

Development of rat soleus endplate membrane following denervation at birth.
MedLine Citation:
PMID:  3572385     Owner:  NLM     Status:  MEDLINE    
Rat soleus endplates develop some of their characteristic features before birth and others after birth. Specializations appearing before birth include a localized cluster of acetylcholine receptors (AChRs), an accumulation of acetylcholinesterase (AChE) in the synaptic basal lamina, and a cluster of nuclei near the endplate membrane. In contrast, postsynaptic membrane folds are elaborated during the first three weeks after birth. We denervated soleus muscles on postnatal day 1, before folds had appeared, and followed the subsequent development of endplate regions with light and electron microscopy. We found that the denervated endplates initiated fold formation on schedule and maintained their accumulations of AChRs, AChE, and endplate nuclei. However, the endplates stopped fold formation prematurely and eventually lost their rudimentary folds. At about the same time, the junctional AChR clusters were joined by ectopic patches of AChRs. The former endplate regions also became unusually elongated, possibly as a consequence of the lack of membrane folds. Apparently, endplate membranes have only a limited capacity for further development in the absence of both the nerve and muscle activity.
B L Moss; S M Schuetze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurobiology     Volume:  18     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-06-11     Completed Date:  1987-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-18     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / growth & development,  physiology*
Membranes / physiology
Motor Endplate / anatomy & histology,  growth & development*,  physiology
Neuromuscular Junction / growth & development*
Rats, Inbred Strains

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