Document Detail


Development of the rat meninx: experimental study using bromodeoxyuridine.
MedLine Citation:
PMID:  2350009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of the rat meninx from the viewpoint of cell proliferation was studied microscopically and immunohistochemically using bromodeoxyuridine (BUdR). A compact cell layer around the neural tube, the meninx primitiva, was observed in 12- and 13-day fetuses. A reticular structure resembling the subarachnoid space appeared in the 14-day fetus. The ectomeninx, consisting of a collagen fiber layer, part of which became the dura mater, appeared in 15-day fetuses, allowing discrimination of the endomeninx, the arachnoid cell layer. The primordium of the choroid plexus also appeared in the lateral ventricle on the same day. Bone appeared in the primitive dura mater, and stratification of the meninx was almost complete in 21-day fetuses. BUdR-positive cells were confirmed in the meninx from day 12 of gestation to day 15 postpartum. The number of BUdR-positive cells was greatest in fetuses aged about 12 or 13 days, reaching nearly 50%, but decreased gradually toward the neonatal period. The findings of this study suggest that, after the migration of neural crest cells, marked cell proliferation in the meninx begins. Differentiation into various layers then follows and is almost complete before birth, whereas the proliferation of arachnoid cells continues even in the early neonatal period.
Authors:
T Kamiryo; T Orita; T Nishizaki; H Aoki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Anatomical record     Volume:  227     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-12     Completed Date:  1990-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Bromodeoxyuridine / diagnostic use*
Cell Division
Embryonic and Fetal Development*
Female
Male
Meninges / cytology,  embryology,  growth & development*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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