| Development of pseudomembranous colitis four months after initiation of rifampicin. | |
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MedLine Citation:
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PMID: 21326858 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment. |
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Authors:
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Jeong Moon Choi; Hyung Hun Kim; Seun Ja Park; Moo In Park; Won Moon |
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Publication Detail:
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Type: Journal Article Date: 2011-01-14 |
Journal Detail:
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Title: Case reports in gastroenterology Volume: 5 ISSN: 1662-0631 ISO Abbreviation: Case Rep Gastroenterol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-07-14 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101474819 Medline TA: Case Rep Gastroenterol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. |
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