Development of the probability of return of spontaneous circulation in intervals without chest compressions during outofhospital cardiac arrest: an observational study.  
Jump to Full Text  
MedLine Citation:

PMID: 19200355 Owner: NLM Status: MEDLINE 
Abstract/OtherAbstract:

BACKGROUND: One of the factors that limits survival from outofhospital cardiac arrest is the interruption of chest compressions. During ventricular fibrillation and tachycardia the electrocardiogram reflects the probability of return of spontaneous circulation associated with defibrillation. We have used this in the current study to quantify in detail the effects of interrupting chest compressions. METHODS: From an electrocardiogram database we identified all intervals without chest compressions that followed an interval with compressions, and where the patients had ventricular fibrillation or tachycardia. By calculating the meanslope (a predictor of the return of spontaneous circulation) of the electrocardiogram for each 2second window, and using a linear mixedeffects statistical model, we quantified the decline of meanslope with time. Further, a mapping from meanslope to probability of return of spontaneous circulation was obtained from a second dataset and using this we were able to estimate the expected development of the probability of return of spontaneous circulation for cases at different levels. RESULTS: From 911 intervals without chest compressions, 5138 analysis windows were identified. The results show that cases with the probability of return of spontaneous circulation values 0.35, 0.1 and 0.05, 3 seconds into an interval in the mean will have probability of return of spontaneous circulation values 0.26 (0.240.29), 0.077 (0.0700.085) and 0.040(0.0360.045), respectively, 27 seconds into the interval (95% confidence intervals in parenthesis). CONCLUSION: During preshock pauses in chest compressions mean probability of return of spontaneous circulation decreases in a steady manner for cases at all initial levels. Regardless of initial level there is a relative decrease in the probability of return of spontaneous circulation of about 23% from 3 to 27 seconds into such a pause. 
Authors:

Kenneth Gundersen; Jan Terje Kvaløy; Jo KramerJohansen; Petter Andreas Steen; Trygve Eftestøl 
Related Documents
:

24741195  Effect of trapidil in myocardial ischemiareperfusion injury in rabbit. 2441915  The nature of ventricular arrhythmias during ergonovineinduced vasospastic angina pect... 
Publication Detail:

Type: Journal Article; Research Support, NonU.S. Gov't Date: 20090206 
Journal Detail:

Title: BMC medicine Volume: 7 ISSN: 17417015 ISO Abbreviation: BMC Med Publication Date: 2009 
Date Detail:

Created Date: 20090330 Completed Date: 20090420 Revised Date: 20091118 
Medline Journal Info:

Nlm Unique ID: 101190723 Medline TA: BMC Med Country: England 
Other Details:

Languages: eng Pagination: 6 Citation Subset: IM 
Affiliation:

Department of Electrical and Computing Engineering, University of Stavanger, Stavanger, Norway. kenneth.gundersen@uis.no 
Export Citation:

APA/MLA Format Download EndNote Download BibTex 
MeSH Terms  
Descriptor/Qualifier:

Cardiopulmonary Resuscitation
/
methods* Electrocardiography / statistics & numerical data Heart Arrest / pathology*, therapy* Humans Survival Analysis Tachycardia* Ventricular Fibrillation* 
Comments/Corrections 
Full Text  
Journal Information Journal ID (nlmta): BMC Med ISSN: 17417015 Publisher: BioMed Central 
Article Information Download PDF Copyright ? 2009 Gundersen et al; licensee BioMed Central Ltd. openaccess: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received Day: 13 Month: 1 Year: 2009 Accepted Day: 6 Month: 2 Year: 2009 collection publication date: Year: 2009 Electronic publication date: Day: 6 Month: 2 Year: 2009 Volume: 7First Page: 6 Last Page: 6 ID: 2661879 Publisher Id: 1741701576 PubMed Id: 19200355 DOI: 10.1186/1741701576 
Development of the probability of return of spontaneous circulation in intervals without chest compressions during outofhospital cardiac arrest: an observational study  
Kenneth Gundersen1  Email: kenneth.gundersen@uis.no 
Jan Terje Kval?y2  Email: jan.t.kvaloy@uis.no 
Jo KramerJohansen3  Email: jo.kramerjohansen@medisin.uio.no 
Petter Andreas Steen45  Email: p.a.steen@medisin.uio.no 
Trygve Eftest?l1  Email: trygve.eftestol@uis.no 
1Department of Electrical and Computing Engineering, University of Stavanger, Stavanger, Norway 

2Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway 

3Institute for Experimental Medical Research, Ulleval University Hospital, Oslo, Norway 

4Faculty Division UUS, University of Oslo, Oslo, Norway 

5Division of Prehospital Emergency Medicine, Ulleval University Hospital, Oslo, Norway 
Recent evidence indicates that cardiopulmonary resuscitation (CPR) during both in and outofhospital cardiac arrest is characterised by frequent and long interruptions in chest compressions [^{1},^{2}]. This reduces vital organ perfusion [^{3}], and in animal experiments, increased length of chest compression pause before shock correlates with reduced rates of return of spontaneous circulation (ROSC) and survival [^{4}^{}^{6}]. Edelson et al. [^{7}] reported that successful defibrillation, defined as removal of ventricular fibrillation (VF) for at least 5 seconds, was associated with shorter preshock pauses in man. Eilevstj?nn et al. [^{8}] reported a similar association for shocks with ROSC outcome but only reported the median length of preshock pauses for ROSC and noROSC shocks. Identifying in detail how pausing in chest compressions affects the vitality of the myocardium, and thereby the probability of ROSC (P_{ROSC}) after defibrillation, is important because it affects treatment priorities before a defibrillation, a vital stage of the resuscitation effort.
During VF and ventricular tachycardia (VT) one can calculate ROSCpredictors from the electrocardiogram (ECG) reflecting the P_{ROSC }associated with defibrillation [^{9}^{}^{12}]. In general terms, we can say that ROSCpredictors reflect the coarseness of the ECG or the vitality of the myocardium. ROSCpredictors have been affected positively by compression sequences both in animals [^{13}] and man [^{14}] and negatively by periods with no chest compressions both in animals [^{15}] and man [^{16}]. Unfortunately, we have now realised that the statistical analysis performed in the last article [^{16}] was flawed. This is explained in Appendix 1. In the current work therefore, we reinvestigate the effect of interruptions of chest compressions on P_{ROSC }calculated from the ECG. Our hypothesis was that P_{ROSC }decreases during such interruptions and that the size of this effect may depend on the absolute value of P_{ROSC}. We use a ROSCpredictor that represents the most accurate, currently available estimate of P_{ROSC }[^{11}], and a statistical methodology that properly handles short time variations of the P_{ROSC }estimate and the fact that the P_{ROSC }level varies from interval to interval [^{17}]. We handle the problem not solved in Eftestol et al. [^{16}] by applying an adequate regression to the data, representing the underlying trends in P_{ROSC }development, and use this to derive our results. Further, we compare the results with relevant data from investigations of animal and human sudden cardiac arrest data.
Data were collected by the respective emergency medical services in an observational prospective study of outofhospital cardiac arrest patients in Akershus (Norway), Stockholm (Sweden) and London (UK) in the period March 2002 to September 2004 [^{1},^{18}]. The appropriate ethical boards at each site approved the study, and the need for informed consent from each patient was waived as decided by these boards in accordance with paragraph 26 of the Helsinki declaration for human medical research. The study is registered as a clinical trial at , (NCT00138996). Continuous ECG, transthoracic impedance, and chest compression depth measurements were collected using a modified Heartstart 4000 (Phillips Medical Systems, Andover, MA, USA) (Heartstart 4000SP (Laerdal Medical, Stavanger, Norway)) and patient records registered according to the Utstein template [^{19}]. The ECG was obtained through the defibrillator's selfadhesive defibrillation pads positioned in lead II equivalent positions and the same types of electrodes were used throughout the data collection. The signal was digitally recorded with a sampling rate of 500 samples per second and 16 bits resolution. Before digital sampling the analogue ECG signal was filtered with a second order bandpass filter with passband of 0.9?50 Hz and before analysis a 48 tap lowpass digital filter with an upper passband edge of 30 Hz was applied to the digitised ECG to remove any 50 Hz power line noise. Regarding the mappingdataset (described below) ROSC was indicated either by a clinically detected pulse or by changes in the transthoracic impedance >50 m? coincident with QRS complexes [^{1}]. Compression depth measurements were used to identify the presence and absence of chest compressions. Further details about registrations and methodology have been given elsewhere [^{1}].
We extracted ECG segments from intervals without chest compressions following an interval with compressions. Only segments with VF or VT during both intervals were included. The ECG segments were then divided into 2second analysis windows centred at 3, 5, 7 and so on up to 27 seconds into the pause, depending on the length of the pause. The first and last 2 seconds of each interval were left out to ensure that the signals were uncorrupted by compression artefacts. We will refer to this dataset as the intervaldataset. ECG segments were manually checked for noise and noisy parts of ECG segments were censored from further analysis. The definition of noise was influence from a pacemaker (regular spikes on the ECG) or short bursts of high frequency signal that visually differ substantially from the surrounding VF or VT. The source of the latter noise form might be electrode noise or muscle artefacts.
The ECG from the analysis windows in the intervaldataset was characterised by computing the logarithm of the meanslope (logslope), one of the most accurate indicators of P_{ROSC }[^{11}]. Meanslope can be viewed as a measurement of the coarseness of the ECG. High amplitude and frequency of the ECG give high meanslope values, indicating a high P_{ROSC}. If ecg(n) is the digitised ECG signal, logslope is defined as
(1)
logslope=ln?(1N?1Necg(n)?ecg(n?1)) 
Logslope values have the desirable property of having an approximate Gaussian distribution, and we thus expected an approximately linear decay with time in untreated VF/VT. A linear mixedeffects model was therefore fitted to logslope versus time. Then a mapping from logslope to P_{ROSC }scale, obtained from a second clinical dataset (described below), was applied to the fitted linear mixedeffects model for easier interpretation.
The mapping from logslope to P_{ROSC }was found from a dataset (mappingdataset) of preshock logslope values and corresponding defibrillation outcomes (ROSC or noROSC) that has previously been described [^{20}]. The mappingdataset was collected during cases of outofhospital cardiac arrest and ROSC was defined as circulating rhythm for a minimum 10% of the postshock interval. A marginal logistic regression model for longitudinal data, accounting for correlation between samples from the same patient [^{21}], was fitted to the mappingdataset using the addon package 'geepack' to the statistical software R (R Development Core Team, R Foundation for Statistical Computing). The mapping function has the following form:
(2)
PROSC(logslope)=e?0+?1?logslope1+e?0+?1?logslope 
?_{0 }and ?_{0 }are parameters of the logistic regression estimated during model fitting. The intervaldataset and the mappingdataset were extracted from the same cardiac arrest episodes. However, since the last 2 seconds of ECG in an interval without chest compressions were not included in the intervaldataset, and we only used the last 2 seconds of ECG before a shock in the mappingdataset, there is in this respect no overlap of data between the datasets.
Using the statistical software Splus (Insightful Corporation, Seattle, WA, USA), we fitted a linear mixedeffects model to the intervaldataset [^{17}]. The linear mixedeffects model takes into account the fact that the general level of logslope varies between intervals by allowing individual variation in the regression parameters from interval to interval. The logslope values are the response variable in the model, and the development of this described with a polynomial in t, where t is time (seconds) after chest compressions stopped minus 10 seconds (t = t_{org}10). The subtraction is performed in order to decorrelate the covariates of the model (t, t^{2}, etc). If i identifies the interval (cluster), the model for the development of logslope with time is given by:
(3)
logslopei(t)=?k=0K?k?tk+?k=0MUik?tk+?it 
K is the polynomial degree for the fixedeffects part of the model and M the degree for the randomeffects part (accounting for variations between intervals) and K ? M. Gaussian model residuals ?_{it }are assumed and also a multivariate Gaussian distribution of the random terms U_{ik}, k ? 1, ..., M
(4) f(U_{i0}, U_{i1}, ..., U_{iM}) = N(0, ?)
The Splus function used to fit the model, lme, has several different possible ways of modelling correlation between residuals within each interval (cluster), and possible heteroschedasticity in the data [^{17}]. We chose the optimal correlation model, variance model (for heteroschedastic data) and the necessary polynomial degree (K and M), in that order, by comparing Akaike information criterion (AIC) values. Polynomial degrees up to four were tested and among possible models with similar AIC values the model of lowest polynomial degrees was chosen. We did not experiment with other variance covariates than the fittedmodel value (software default). For mathematical details about the modelling of correlation between residuals and heteroschedastic data we refer to Pinheiro and Bates [^{17}]. After choosing our final model it was validated by plotting normal probability plots for the model residuals and the random terms, the distribution of residuals against time and fittedmodel value and the response against fitted values.
The linear mixedeffects model was fitted to logslope values due to the statistical properties mentioned above, but we wanted to interpret the implications on the P_{ROSC }scale. More specifically we wanted to find the expected development of P_{ROSC }for intervals with different starting values. To avoid the random short time variation in logslope (and P_{ROSC}) from influencing the development, we relate each expected development to the starting value of the regression, representing the true underlying behaviour. The results are derived from the fitted linear mixedeffects model (not from specific regression lines for each interval) and the obtained mapping from logslope to P_{ROSC}. Further descriptions of these procedures are given in Appendix 2.
We present the estimated parameters of the chosen linear mixedeffects model and of the logistic regression model for the logslope to P_{ROSC }mapping, along with 95% confidence intervals (CI) or standard deviation (Std) of estimates for all parameters. Further we present estimates of the expected development with time (into the intervals without compressions) of P_{ROSC }for intervals with different starting values. Approximate 95% CIs for the P_{ROSC }developments are derived by drawing 1000 simulated parameter values from the model parameters asymptotic distributions, and then recalculating the resulting P_{ROSC }values for each simulation. The 95% CI for the estimated expected P_{ROSC }developments are defined as the 95% CI of P_{ROSC }at a given time into an interval, given a chosen P_{ROSC }value at the first point of analysis (3 seconds into the intervals).
Data from 530 defibrillation attempts given to 86 patients were included in the mappingdataset and used to estimate the logslope to P_{ROSC }mapping. In the mappingdataset logslope has an area under the ROSC curve of 0.876 when used to predict which defibrillations will result in ROSC. A histogram of these data is plotted along with the estimated mapping in Figure 1.
Logslope values from 911 intervals without chest compressions were included in the intervaldataset and the median interval without chest compressions had five analysis windows. Out of 6229 analysis windows, 17.6% were excluded because of noise in the ECG, leaving 5138. From the complete records of 363 patients, 134 patients had intervals that were included. By comparing AIC values of different candidate models we identified a linear mixedeffects model with an exponential spatial correlation model with nugget effect, polynomial degrees K = 1 and M = 1, and an exponential variance function. Given that a linear model in t (polynomials of degree one) was chosen shifting of the time covariate is not necessary, but in order to simplify calculations a time shift of 3 seconds (t = t_{org}3) was used when estimating the final model.
Estimated model parameters of the logistic regression model for the logslope to P_{ROSC }mapping and of the chosen linear mixedeffects model are given in Table 1. The logslope value on average decreases 0.00601 per second in our data range (3 to 27 seconds into an interval without chest compressions). The diagnostic plots confirmed that the linear mixedeffects model is adequate for the data.
The data in the intervaldataset and how the linear mixedeffects model represents these are illustrated by Figure 2. The figure shows the logslope values and fittedmodel values of three intervals. We observe that the intervals are of different length, have logslope values at different levels, and that the fitted lines are allowed to have different intercepts and slopes. The fitted values of Standard deviation(U_{0}), Standard deviation(U_{1}) and correlation(U_{0}, U_{1}) given in Table 1 describe how the intercepts and slopes are distributed in our data.
Using Equation (8) in Appendix 2 we computed a set of expected developments of P_{ROSC }given different P_{ROSC }values 3 seconds into an interval, shown in Figure 3. According to the ?_{0 }parameter, the logslope value 3 seconds into an interval has a Gaussian distribution with mean 5.224 and standard deviation 0.594 (Std(U_{0})) in our dataset, and we characterise each development by the quantile the initial logslope value (corresponding to the chosen initial P_{ROSC }value) is at in this distribution. About 60% of the intervals have initial P_{ROSC }below 0.1.
Using the approach described in Appendix 2 we estimate that if all the intervals without chest compressions were shocked with 3 seconds preshock pause the mean P_{ROSC }would be 0.126, while with 27 seconds pause it would be 0.0971. The estimated relative decrease in mean P_{ROSC}, 1(0.0971/0.1255) ? 0.23, (95% CI: 0.17?0.29) is comparable with that in each of the developments in Figure 3, meaning that independent of the absolute P_{ROSC }level about 23% of the chance of ROSC will be lost with increasing the preshock pause in chest compressions from 3 to 27 seconds.
Our analysis shows that P_{ROSC}, as determined from ECG analysis, decreases in a steady manner with time in VF/VT intervals without chest compressions for all initial values of P_{ROSC}. This shows that limiting interruption in chest compressions is important for patients in all states and that every second without perfusion has a negative effect on P_{ROSC}. The current results therefore give support for a strong focus on improving CPR quality.
Unlike the results of Eftestol et al. [^{16}], the current results show that P_{ROSC }does not decrease sharply during the first 5 seconds of an interruption. Therefore, a preshock pause in compressions of a couple of seconds to ensure the safety of EMS personnel, or to perform rhythm analysis on artefactfree ECG, may be acceptable. Concerning safety, preshock pauses of 1 to 2 seconds might be sufficient as it has been argued that the risks of accidental defibrillation of resuscitation providers have been over emphasised [^{22}]. Further, the accuracy of rhythm analysis during ongoing compressions might in the future be improved as a result of either improved artefact removal algorithms or of using dedicated ECG recording electrodes generating fewer artefacts than combined recording and defibrillation electrodes [^{23}]. This will also reduce the need for preshock pauses in compressions. Although the current results show that preshock interruptions in compressions should be minimised, they do not indicate that it is critical, although favourable, for the outcome of resuscitation to compress during defibrillation. This is because there is no indication of a sharp decrease in P_{ROSC }during the first few seconds of an interruption.
The effect of preshock interruptions in chest compressions on resuscitation outcome or ROSC has also been studied in animals [^{4}^{}^{6}]. In agreement with the current results all three studies found a clear negative effect of longer preshock interruptions. Edelson et al. [^{7}] found strong negative correlation between duration of preshock interruptions on first shock success in humans, defined as removal of VF for at least 5 seconds following defibrillation, but no significant effect of preshock pause duration on ROSC or survival to hospital discharge. It was stated that one possible reason for this was the limited dataset with lower incidence of ROSC and survival than of shock success with the possibility of a statistical type II error. Eilevstj?nn et al. [^{8}] found that the median length of preshock interruption of chest compressions for ROSC was 15 seconds versus 18 seconds for noROSC shocks (P = 0.008), but did not quantify further the negative effect of increasing length of interruptions.
A limitation of our approach is that the effect was studied indirectly by using the established fact that the P_{ROSC }can be estimated from the ECG waveform [^{9}^{}^{12}], instead of by direct analysis of the relation between preshock pause length and rate of ROSC. The latter could however, only have identified how the mean probability of ROSC for the population would be influenced by increasing preshock pauses in CPR, and could not have identified possible differences in the development for cases with different probabilities of ROSC at the start of the preshock interval without chest compressions. Using ECG analysis we can estimate P_{ROSC }continuously for every available interval without chest compressions that follow an interval with chest compressions and, therefore, estimate the expected development of P_{ROSC }for cases at different starting levels. A further limitation is that we excluded from the analysis all segments where the ECG apparently was affected by a pacemaker and one group of patients was therefore excluded from the analysis. Performing a reanalysis including also the data with noise did however only produce minor changes in the results. At last, the effects of right ventricular dilation and left ventricular contraction occurring during interruptions in compressions, described by Chamberlain et al. [^{24}], may not be reflected in the ECG waveform. The current results may in this respect possibly underestimate the detrimental effect of interrupting compressions.
We have shown that the probability of ROSC estimated from the ECG decreases in a steady manner with increasing preshock pauses in chest compressions. Regardless of initial level, there is a relative decrease in the estimated probability of ROSC of about 23% from 3 to 27 seconds, or, in other words, a 1% relative decrease for every second into such a pause.
AIC: Akaike information criterion; CI: confidence interval; CPR: cardiopulmonary resuscitation; ECG: electrocardiogram; P_{ROSC:}probability of return of spontaneous circulation; ROSC: return of spontaneous circulation; Std: standard deviation; VF: ventricular fibrillation; VT: ventricular tachycardia
PAS is a member of the board of directors for Laerdal Medical. All other authors declare that they have no competing interests.
KG conceived the study, developed and performed the analysis and drafted the manuscript. JTK contributed to the development of the analysis methods. JKJ and PAS contributed to the acquisition and preparation of data. TE contributed to the conception of the study and to the preparation of data. All authors have revised and approved the final manuscript.
This section describes why we claim that the analysis in Eftestol et al. [^{16}] was flawed. That particular paper is the only previous study to use ECG analysis on clinical data to investigate the effects of interrupting chest compressions on the probability of ROSC. In Eftestol et al. [^{16}], the ECG segments (from preshock VF intervals without chest compressions) were divided into three groups, one for those with an initially high P_{ROSC }value (the first P_{ROSC }value in the segment >0.4), one with medium initial values (0.25< first P_{ROSC }< 0.40), and one with low initial values (<0.25). After this the development with time of the median of P_{ROSC }in the segments in these three groups was calculated. However, there are quite large random short time variations, or measurement noise, in the P_{ROSC }estimate used [^{25}], and these influence the group to which the segments are assigned in the first place. Therefore, for the group of segments with high initial P_{ROSC }value a large proportion of the segments will have high values only at the start of the segment. The median of each group will approach the median of all the segments for the consecutive measurements. We can demonstrate this by reanalysis of the original data from Eftestol et al. [^{16}], but assign the segments to three groups according to the P_{ROSC }values at 10 seconds into the segments rather than according to the initial values. The result of this is shown together with the original plot from Eftestol et al. [^{16}] in Figure 4. If the P_{ROSC }estimate from each ECG segment had little or no random variation between consecutive measurements, this modification of the analysis should have little effect on the results. However, changing the time at which the assignment to groups is performed totally changes the plot and we must, therefore, conclude that the analysis is flawed. The inadequate analysis led to unjustified conclusions, most prominently for the 'high' and 'low' subgroups. For cases with a high initial level a dramatic decrease in median P_{ROSC }(from 0.5 to 0.25) with only 5 seconds interruption in chest compressions was falsely indicated, and for the group of cases with low initial P_{ROSC}, representing 85% of the total number of cases, it was indicated that the median P_{ROSC }is stable or slightly increasing during interruptions of up to 20 seconds, despite there being no coronary perfusion. It should be noted that two of the authors (TE and PAS) of the criticised article are also coauthors of the current article.
If we choose value x at t = 0 for the regression to logslope, for a hypothetical interval h by choosing U_{h0 }= x ?_{0}, we can estimate the development of the mean P_{ROSC }for intervals with a specific starting value. In this way the estimated development is not influenced by the random short time variation in logslope at t = 0, represented by ?_{h0}. By analogy, this was the problem with the analysis performed by Eftestol et al. [^{16}]. With the above choice of U_{h0 }the marginal distribution of the other random terms is given by:
(5)
fm(Uh1,...,UhM)=f(x??0,Uh1,...,UhM)????..????f(x??0,Uh1,...,UhM)dUh1,....dUhM 
the model for the logslope at t by:
(6)
logslopeh(t,Uh1,...,UhMUh0+?0=x)=x+?k=1K?k?tk+?k=1MUhk?tk+?ht 
and, using Equation (2) for the logslope to P_{ROSC }mapping, the model for P_{ROSC }at t is given by:
(7)
PROSC,h(t,Uh1,...,UhMUh0+?0=x)=exp?(?0+?1?(x+?k=1K?k?tk+?k=1MUhk?tk+?ht))1+exp?(?0+?1?(x+?k=1K?k?tk+?k=1MUhk?tk+?ht)) 
Then the expected P_{ROSC }development given the chosen initial value can be calculated by:
(8)
E[PROSC,h(t)Uh0+?0=x]=????..????PROSC,h(t,Uh1,...,UhMUh0+?0=x)?fm(Uh1,...,UhM)?f(?ht)dUh1,..,dUhM,d?ht 
By choosing different values for x we can calculate the expected P_{ROSC }development for cases with different starting values. For a given starting value of P_{ROSC}, the corresponding logslope value x is found using Equation (2). If we make no specific choice of logslope at t = 0, but modify Equation (8) to integrate out the random intercept U_{h0 }as well as the other random terms, we can obtain an estimate for how the mean P_{ROSC }develops with time, pooling together cases at all P_{ROSC }levels.
The prepublication history for this paper can be accessed here:
The efforts of all ambulance personnel and local coordinators of data collection in Akerhus (Hallstein S?reb?), Stockholm (Leiv Svensson) and London (Bob Fellows) are highly appreciated. KG was at the time of the study a PhD student funded by the Norwegian Research Council, project number 27529. TE is the project manager of the same project. The project [^{1},^{18}], from which the data originated, was funded by the Norwegian Air Ambulance Foundation (PhD scholarship for JKJ), Regional Health Authorities East (PAS), Laerdal Medical, Stavanger Norway (provided the prototype defibrillators, data collection server, and expenses for extra training related to data collection) and Philips Medical Systems, Andover, MA, USA (original defibrillators). None of these had further involvement in developing the data analysis or writing this article.
References
Wik L,KramerJohansen J,Myklebust H,Sorebo H,Svensson L,Fellows B,Steen PA. Quality of cardiopulmonary resuscitation during outofhospital cardiac arrestJAMA 2005;293:299–304. [pmid: 15657322] [doi: 10.1001/jama.293.3.299]  
Abella BS,Alvarado JP,Myklebust H,Edelson DP,Barry A,O'Hearn N,Hoek TL Vanden,Becker LB. Quality of cardiopulmonary resuscitation during inhospital cardiac arrestJAMA 2005;293:305–310. [pmid: 15657323] [doi: 10.1001/jama.293.3.305]  
Berg RA,Sanders AB,Kern KB,Hilwig RW,Heidenreich JW,Porter ME,Ewy GA. Adverse hemodynamic effects of interrupting chest compressions for rescue breathing during cardiopulmonary resuscitation for ventricular fibrillation cardiac arrestCirculation 2001;104:2465–2470. [pmid: 11705826] [doi: 10.1161/hc4501.098926]  
Sato Y,Weil MH,Sun S,Tang W,Xie J,Noc M,Bisera J. Adverse effects of interrupting precordial compression during cardiopulmonary resuscitationCrit Care Med 1997;25:733–736. [pmid: 9187589] [doi: 10.1097/0000324619970500000005]  
Steen S,Liao Q,Pierre L,Paskevicius A,Sjoberg T. The critical importance of minimal delay between chest compressions and subsequent defibrillation: a haemodynamic explanationResuscitation 2003;58:249–258. [pmid: 12969599] [doi: 10.1016/S03009572(03)00265X]  
Yu T,Weil MH,Tang W,Sun S,Klouche K,Povoas H,Bisera J. Adverse outcomes of interrupted precordial compression during automated defibrillationCirculation 2002;106:368–372. [pmid: 12119255] [doi: 10.1161/01.CIR.0000021429.22005.2E]  
Edelson DP,Abella BS,KramerJohansen J,Wik L,Myklebust H,Barry AM,Merchant RM,Hoek TLV,Steen PA,Becker LB. Effects of compression depth and preshock pauses predict defibrillation failure during cardiac arrestResuscitation 2006;71:137–145. [pmid: 16982127] [doi: 10.1016/j.resuscitation.2006.04.008]  
Eilevstjonn J,KramerJohansen J,Sunde K. Shock outcome is related to prior rhythm and duration of ventricular fibrillationResuscitation 2007;75:60–67. [pmid: 17467139] [doi: 10.1016/j.resuscitation.2007.02.014]  
Amann A,Rheinberger K,Achleitner U. Algorithms to analyze ventricular fibrillation signalsCurr Opin Crit Care 2001;7:152–156. [pmid: 11436521] [doi: 10.1097/0007519820010600000003]  
Eftestol T,Sunde K,Aase SO,Husoy JH,Steen PA. Predicting outcome of defibrillation by spectral characterization and nonparametric classification of ventricular fibrillation in patients with outofhospital cardiac arrestCirculation 2000;102:1523–1529. [pmid: 11004143]  
Neurauter A,Eftest?l T,KramerJohansen J,Abella BS,Sunde K,Volker W,Lindner KH,Eilevstj?nn J,Myklebust H,Steen PA,Strohmenger HU. Prediction of countershock success using single features from multiple ventricular fibrillation frequency bands and feature combinations using neural networksResuscitation 2007;73:253–263. [pmid: 17287063] [doi: 10.1016/j.resuscitation.2006.10.002]  
Povoas HP,Weil MH,Tang WC,Bisera J,Klouche K,Barbatsis A. Predicting the success of defibrillation by electrocardiographic analysisResuscitation 2002;53:77–82. [pmid: 11947983] [doi: 10.1016/S03009572(01)004889]  
Berg RA,Hilwig RW,Kern KB,Ewy GA. Precountershock cardiopulmonary resuscitation improves ventricular fibrillation median frequency and myocardial readiness for successful defibrillation from prolonged ventricular fibrillation: A randomized, controlled swine studyAnn Emerg Med 2002;40:563–570. [pmid: 12447331] [doi: 10.1067/mem.2002.129866]  
Eftestol T,Wik L,Sunde K,Steen PA. Effects of cardiopulmonary resuscitation on predictors of ventricular fibrillation defibrillation success during outofhospital cardiac arrestCirculation 2004;110:10–15. [pmid: 15210599] [doi: 10.1161/01.CIR.0000133323.15565.75]  
Brown CG,Dzwoncyzk R,Martin DR. Physiologic measurement of the ventricular fibrillation ECG signal: Estimating the duration of ventricular fibrillationAnn Emerg Med 1993;22:70–74. [pmid: 8424618] [doi: 10.1016/S01960644(05)802537]  
Eftestol T,Sunde K,Steen PA. Effects of interrupting precordial compressions on the calculated probability of defibrillation success during outofhospital cardiac arrestCirculation 2002;105:2270–2273. [pmid: 12010909] [doi: 10.1161/01.CIR.0000016362.42586.FE]  
Pinheiro JC,Bates DM. Mixedeffects Models in S and SPLUS. 2000New York: Springer;  
KramerJohansen J,Myklebust H,Wik L,Fellows B,Svensson L,Sorebo H,Steen PA. Quality of outofhospital cardiopulmonary resuscitation with real time automated feedback: A prospective interventional studyResuscitation 2006;71:283–292. [pmid: 17070980] [doi: 10.1016/j.resuscitation.2006.05.011]  
Jacobs I,Nadkarni V,Bahr J,Berg RA,Billi JE,Bossaert L,Cassan P,Coovadia A,D'Este K,Finn J,Halperin H. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: A statement for healthcare professionals from a task force of the international liaison committee on resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa)Resuscitation 2004;63:233–249. [pmid: 15582757] [doi: 10.1016/j.resuscitation.2004.09.008]  
Gundersen K,Kvaloy JT,KramerJohansen J,Eftestol T. Identifying approaches to improve the accuracy of shock outcome prediction for outofhospital cardiac arrestResuscitation 2008;76:279–284. [pmid: 17767991] [doi: 10.1016/j.resuscitation.2007.07.019]  
Diggle P. Analysis of Longitudinal Data (2). 20022. Oxford: Oxford University Press;  
Perkins GD,Lockey AS. Defibrillation ? safety versus efficacyResuscitation 2008;79:1–3. [pmid: 18692290] [doi: 10.1016/j.resuscitation.2008.06.018]  
Fitzgibbon E,Berger R,Tsitlik J,Halperin HR. Determination of the noise source in the electrocardiogram during cardiopulmonary resuscitationCrit Care Med 2002;30:S148–S153. [pmid: 11953642] [doi: 10.1097/0000324620020400100006]  
Chamberlain D,Frenneaux M,Steen S,Smith A. Why do chest compressions aid delayed defibrillation?Resuscitation 2008;77:10–15. [pmid: 18207623] [doi: 10.1016/j.resuscitation.2007.11.010]  
Eftestol T,Sunde K,Aase SO,Husoy JH,Steen PA. 'Probability of successful defibrillation' as a monitor during CPR in outofhospital cardiac arrested patientsResuscitation 2001;48:245–254. [pmid: 11278090] [doi: 10.1016/S03009572(00)002665] 
Figures
Tables
Estimated parameter values of statistical models
Chosen linear mixedeffects model  
Parameter  Estimate  95% confidence interval 


?_{0}  5.224  [5.263?5.184] 
?_{1}  0.00601  [0.00712?0.00490] 
Standard deviation (U_{0})  0.594  [0.564 0.6324] 
Standard deviation (U_{1})  0.00708  [0.00564 0.00889] 
Correlation (U_{0}, U_{1})  0.201  [0.366?0.0416] 
Range  3.11  [1.64 5.88] 
Nugget  0.520  [0.401 0.629] 
Power  0.598  [0.805?0.391] 


Logistic regression model  


Parameter  Estimate  Standard deviation 


?_{0}  9.28  1.51 
?_{1}  2.26  0.315 
Estimated model parameters of the chosen linear mixedeffects model and the marginal logistic regression model for the logslope to probability of return of spontaneous circulation (P_{ROSC) }mapping. ?_{0 }and ?_{1 }are the fixedeffects parameters. Standard deviation (U_{0}), standard deviation (U_{1}) and correlation (U_{0}, U_{0}) give the properties of the zeromean bivariate Gaussian distribution of the randomeffects terms. Range and nugget are parameters in the model for correlation between residuals. Power is the parameter in the variance function. ?_{0 }is the intercept in the logistic regression models linear function, and ?_{1 }represents the change in logodds ratio (ROSC versus noROSC) with a unit change in the covariate (logslope).
Article Categories:

Previous Document: A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes b...
Next Document: A randomised controlled trial of structured nurseled outpatient clinic followup for dyspeptic pati...