Document Detail

Development of pro- and antisaccades in children with attention-deficit hyperactivity disorder (ADHD) and healthy controls.
MedLine Citation:
PMID:  12756978     Owner:  NLM     Status:  MEDLINE    
To date, the investigation of the antisaccade task, a simple test of "executive functions," in children with ADHD has yielded inconsistent results. The present study aimed at contributing to this issue by (a) the investigation of a large sample of carefully diagnosed ADHD patients aged 7-15 years, and (b) the analyses of differential age effects in patients and controls. Healthy control children were pairwise matched with patients (N = 46; age = 136 +/- 24 months) for age and gender, and did not significantly differ in IQ. Horizontal pro- and antisaccades were elicited under the 200-ms gap and overlap conditions (blocks of 100 trials each). Overall, patients exhibited (a) augmented pro- and antisaccadic reaction times, (b) augmented error rates (antitasks), (c) augmented proportions of early responses (all conditions), and (d) reduced proportions of express saccades under the prosaccadic gap condition. The greater decline in anti- as compared to pro-SRT with increasing age that characterized controls was missing in patients. Confirming Barkley's (1997) neuropsychological theory of ADHD, these results altogether point to alterations in "executive functions" in ADHD patients that are presumably supported by frontal lobe structures, in particular the lateral prefrontal cortex and the frontal eye fields.
C H Klein; A Raschke; A Brandenbusch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  40     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-06-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-28     Citation Subset:  IM    
Department of Psychology, Research Group Psychophysiology, University of Freiburg, Freiburg, Germany.
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MeSH Terms
Aging / psychology
Attention Deficit Disorder with Hyperactivity / psychology*
Photic Stimulation
Psychiatric Status Rating Scales
Reaction Time / physiology
Saccades / physiology*

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