Document Detail


Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers.
MedLine Citation:
PMID:  18382526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A near-infrared Raman system was developed to collect real-time in vivo human lung spectra. The excitation light and the emission were guided to and from the tissue surface by a reusable fiber catheter passed down the instrument channel of a bronchoscope. Two-stage filtering was used to reduce laser noise, fluorescence, and Raman emissions from the fibers. A second fiber bundle guided the emission to a spectrometer where the fibers, in a round packing geometry, were spread out to form a parabolic arc that improved the signal-to-noise ratio 20-fold, facilitating real-time spectral measurements. Preliminary clinical tests show that clear and reliable Raman spectra can be obtained.
Authors:
Michael A Short; Stephen Lam; Annette McWilliams; Jianhua Zhao; Harvey Lui; Haishan Zeng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  33     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  711-3     Citation Subset:  IM    
Affiliation:
Cancer Imagin Department, British Columbia Cancer Research Centre, Vancouver, B.C., Canada.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Bronchoscopes
Bronchoscopy / methods
Calibration
Endoscopy / methods*
Equipment Design
Humans
Lasers
Lung / pathology*
Lung Neoplasms / metabolism*,  pathology*
Sensitivity and Specificity
Spectrometry, Fluorescence / methods
Spectrum Analysis, Raman / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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