| Development of a point-of-care device for the quantification of bilirubin in cerebral spinal fluid. | |
| | |
MedLine Citation:
|
PMID: 21096772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
In North America, an estimated 30,000 patients annually experience an aneurysmal subarachnoid hemorrhage (SAH). In approximately five percent of these patients, the hemorrhage is not visible on computerized tomography scans due to the inability to image blood at time intervals greater than 12 hours post symptom onset. For these patients (many of which have experience a sentinel hemorrhage that is a precursor to a more significant rupture) a method is needed for accurately analyzing cerebral spinal fluid (CSF) for evidence of SAH. Further, it is necessary to differentiate blood associated with the SAH from blood associated with the spinal tap procedure. This paper presents the development of a point-of-care device that is capable of performing such an analysis. The stand alone prototype device uses commercially available embedded system components to implement a hardware platform that is capable of collecting and analyzing optical absorbance spectra. A mathematical model for the hemorrhagic CSF sample is then developed using a PLSR based regression methodology that is able to differentiate between SAH and blood associated with the spinal tap. This differentiations in achieved by quantifying bilirubin (associated with the breakdown of old blood) in the CSF. Initial testing on the prototype device suggests that the device is able to quantify bilirubin in the presence of hemoglobin over concentrations ranges that are clinically relevant to the patient population of interest. |
| | |
Authors:
|
Fred R Beyette; Blaine Booher; James Drennan; Lee Carraher; Josh Butler; Peggy Bowman; Joseph F Clark; Philip A Wilsey |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 1 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
|
Languages: eng Pagination: 915-8 Citation Subset: IM |
Affiliation:
|
School of Electronics and Computing Systems, University of Cincinnati, OH 45221-0030 USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of respiratory waveforms using non-contact electrodes during bathing.
Next Document: Instrumentation for the analysis of airflow limitation by the negative expiratory pressure technique...