| Development of the pig placenta. | |
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MedLine Citation:
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PMID: 19848293 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Placental insufficiency results in fetal loss, low birth weight, stillbirth, preweaning mortality and poor growth. Placental development begins at conceptus elongation, which is a primary factor controlling the size of the placenta. After elongation, the allantois develops outward from the embryo to establish the allantochorion, which defines the size of the functional placenta. During implantation, chorionic trophoblasts adhere to endometrial epithelial cells. Placental structures known as areolae develop at the openings of the endometrial glands and take up endometrial gland secreted products (histotrophe). Between day 30 and 35 of gestation, the adhered trophoblast-endometrial epithelial bilayer undergoes microscopic folding. Fetal and maternal capillaries develop adjacent to the bilayer and blood flows are arranged in a cross-countercurrent manner. Except for nutrients secreted by the glands, nutrient exchange takes place between these capillaries within these folds. By day 85, the folds deepen and become more complex, increasing surface area. The epithelial bilayer thins and capillaries indent the plane of each layer (but do not penetrate), reducing distance between capillaries. The folded bilayer is surrounded by endometrial stroma on the maternal side and placental stroma on the fetal side. The fetal-placental stroma is partially composed of glycosaminoglycans, the most abundant being hyaluronan and heparan sulfate. Changes in both hyaluronoglucosaminidase and heparanase during placental development suggest that these enzymes play a role in placental development. In addition to structural modifications, various nutrient specific transport mechanisms exist. These mechanisms are likely to be as important to transport of specific nutrients as placental size or structure. |
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Authors:
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J L Vallet; J R Miles; B A Freking |
Related Documents
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6197223 - Endocrine assessments of fetal-placental well-being. 6437433 - Permeability of the human placenta to bicarbonate: in-vitro perfusion studies. 6197223 - Endocrine assessments of fetal-placental well-being. |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Society of Reproduction and Fertility supplement Volume: 66 ISSN: - ISO Abbreviation: Soc Reprod Fertil Suppl Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101295315 Medline TA: Soc Reprod Fertil Suppl Country: England |
Other Details:
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Languages: eng Pagination: 265-79 Citation Subset: IM |
Affiliation:
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USDA, ARS, U.S. Meat Animal Research Center, P. O. Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA. jeff.vallet@ars.usda.gov |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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