| Development and pharmacokinetic evaluation of erythromycin lipidic formulations for oral administration in rainbow trout (Oncorhynchus mykiss). | |
| | |
MedLine Citation:
|
PMID: 21402156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this work was to enhance the bioavailability of erythromycin base when administered orally in rainbow trout (Oncorhynchus mykiss). Since erythromicin is normally given in the form of medicated feed, in this study 3 new types of feed formulation were developed. A self-emulsifying system and two types of double microemulsions (O/W/O) were prepared, characterised and adsorbed on a commercial extruded diet for fish. The emulsified systems were based on saturated polyglycolized glycerides and mono- and diglycerides of medium chain fatty acids (as oily phase), Tween(®) 80 (as surfactant) and, in the case of double microemulsions, distilled water. The systems differed in percentage composition and for the amount and position of erythromycin in different phases. The three medicated feed were then administered orally by means of a gastric probe to rainbow trout and their relative bioavailability was estimated in comparison to that obtained after oral administration of feed with erythromycin powder. For each medicated feed, 80 fish were tested. Finally, plasma profiles of erythromycin after single administration of medicated feeds were used to predict profiles obtainable by administering once daily medicated feeds for 7 consecutive days. The results proved that the feeds containing microemulsified erythromycin provided largely superior oral bioavailability and the advantage of obtaining the same efficacy against bacterial infections with a much lower dose of drug. |
| | |
Authors:
|
Francesca Serdoz; Dario Voinovich; Beatrice Perissutti; Iztok Grabnar; Dritan Hasa; Rodolfo Ballestrazzi; Ettore Coni; Enrico Pellegrini |
Related Documents
:
|
1117766 - Changinc concepts in malignant melanoma. 2108416 - Intraoperative facial nerve monitoring. technical aspects. 21540686 - Patient safety in the nicu: a comprehensive review. 21501076 - Clinical profiles of primary open angle glaucoma versus normal tension glaucoma patient... 9341686 - Differences in pain medication use in stroke patients with aphasia and without aphasia. 8973236 - Nuremberg lamentation: for the forgotten victims of medical science. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
|
Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Volume: - ISSN: 1873-3441 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9109778 Medline TA: Eur J Pharm Biopharm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation.
Next Document: Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomed...