Document Detail

Development of peptidergic systems in the rat brain.
MedLine Citation:
PMID:  6279364     Owner:  NLM     Status:  MEDLINE    
The brain contains a large variety and number of peptides some of which were known earlier as hypothalamic hormones (vasopressin, oxytocin, luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, somatostatin) or as pituitary hormones (the family of opiomelanocortins), while others, not primarily known as hypothalamic or pituitary hormones, may also have endocrine effects (substance P, angiotensin II, neurotensin, bombesin, vasoactive intestinal peptide (VIP), gastrin-cholecystokinin, glucagon, carnosine, bradykinin). These peptides, which form a new class of putative neurotransmitters, are present early in brain development and show important sex differences in both their pattern of innervation and their effects. Their peripheral effects may include intrauterine growth of the placenta and fetus, the timing of birth, acceleration of the course of labour and responses to haemorrhage (redistribution of cardiac output and stimulation of blood cell formation). Endogenous peptides are probably involved in brain development, which may explain their general, permanent and sex-dependent effects when given in the period of rapid brain development. Although peptides might in the future be useful for stimulating recovery from retarded brain development, at present one should be aware of the potential dangers of their use in, for example, obstetrics.
D F Swaab; J P Ter Borg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  86     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1981  
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  271-94     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology
Angiotensin II / physiology
Brain / physiology*
Brain Chemistry
Fetus / analysis,  drug effects,  physiology*
Hypothalamic Hormones / analysis
Melanocyte-Stimulating Hormones / pharmacology
Oxytocin / physiology
Peptides / analysis,  physiology*
Pituitary Hormones / analysis
Sex Factors
Thyrotropin-Releasing Hormone / pharmacology
Vasopressins / physiology
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Peptides; 0/Pituitary Hormones; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 24305-27-9/Thyrotropin-Releasing Hormone; 50-56-6/Oxytocin; 9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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