Document Detail


Development of partial life-cycle experiments to assess the effects of endocrine disruptors on the freshwater gastropod Lymnaea stagnalis: a case-study with vinclozolin.
MedLine Citation:
PMID:  20623335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term effects of endocrine disruptors (EDs) on aquatic invertebrates remain difficult to assess, mainly due to the lack of appropriate sensitive toxicity test methods and relevant data analysis procedures. This study aimed at identifying windows of sensitivity to EDs along the life-cycle of the freshwater snail Lymnaea stagnalis, a candidate species for the development of forthcoming test guidelines. Juveniles, sub-adults, young adults and adults were exposed for 21 days to the fungicide vinclozolin (VZ). Survival, growth, onset of reproduction, fertility and fecundity were monitored weekly. Data were analyzed using standard statistical analysis procedures and mixed-effect models. No deleterious effect on survival and growth occurred in snails exposed to VZ at environmentally relevant concentrations. A significant impairment of the male function occurred in young adults, leading to infertility at concentrations exceeding 0.025 μg/L. Furthermore, fecundity was impaired in adults exposed to concentrations exceeding 25 μg/L. Biological responses depended on VZ concentration, exposure duration and on their interaction, leading to complex response patterns. The use of a standard statistical approach to analyze those data led to underestimation of VZ effects on reproduction, whereas effects could reliably be analyzed by mixed-effect models. L. stagnalis may be among the most sensitive invertebrate species to VZ, a 21-day reproduction test allowing the detection of deleterious effects at environmentally relevant concentrations of the fungicide. These results thus reinforce the relevance of L. stagnalis as a good candidate species for the development of guidelines devoted to the risk assessment of EDs.
Authors:
Virginie Ducrot; Mickaël Teixeira-Alves; Christelle Lopes; Marie-Laure Delignette-Muller; Sandrine Charles; Laurent Lagadic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-11
Journal Detail:
Title:  Ecotoxicology (London, England)     Volume:  19     ISSN:  1573-3017     ISO Abbreviation:  Ecotoxicology     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-07     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9885956     Medline TA:  Ecotoxicology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1312-21     Citation Subset:  IM    
Affiliation:
INRA, Équipe Écotoxicologie et Qualité des Milieux Aquatiques, UMR985 Ecologie et Santé des Ecosystèmes, Agrocampus Ouest, 65 rue de Saint Brieuc, 35000, Rennes, France. virginie.ducrot@rennes.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Androgen Antagonists / toxicity*
Animals
Ecotoxicology
Female
Fresh Water
Fungicides, Industrial / toxicity*
Life Cycle Stages
Lymnaea / drug effects*,  growth & development
Male
Oxazoles / toxicity*
Reproduction
Risk Assessment
Toxicity Tests
Water Pollutants, Chemical / toxicity
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 0/Fungicides, Industrial; 0/Oxazoles; 0/Water Pollutants, Chemical; 50471-44-8/vinclozolin

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