Document Detail

Development of the pacemaker tissues of the heart.
MedLine Citation:
PMID:  20133910     Owner:  NLM     Status:  MEDLINE    
Pacemaker and conduction system myocytes play crucial roles in initiating and regulating the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging cause dysfunction of the pacemaker and conduction tissues, emphasizing the clinical necessity to understand the molecular and cellular mechanisms of their development and homeostasis. Although all cardiac myocytes of the developing heart initially possess pacemaker properties, the majority differentiates into working myocardium. Only small populations of embryonic myocytes will form the sinus node and the atrioventricular node and bundle. Recent efforts have revealed that the development of these nodal regions is achieved by highly localized suppression of working muscle differentiation, and have identified transcriptional repressors that mediate this process. This review will summarize and reflect new experimental findings on the cellular origin and the molecular control of differentiation and morphogenesis of the pacemaker tissues of the heart. It will also shed light on the etiology of inborn and acquired errors of nodal tissues.
Vincent M Christoffels; Gertien J Smits; Andreas Kispert; Antoon F M Moorman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  106     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-54     Citation Subset:  IM    
Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
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MeSH Terms
Gene Expression Regulation, Developmental
Heart / embryology,  physiology*
Heart Conduction System / embryology,  physiology*
Models, Biological
Myocardial Contraction / physiology*
Myocardium / cytology,  metabolism
Sinoatrial Node / embryology,  physiology*
T-Box Domain Proteins / genetics,  metabolism
Reg. No./Substance:
0/T-Box Domain Proteins

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