Document Detail

Development and optimization of iron- and zinc-containing nanostructured powders for nutritional applications.
MedLine Citation:
PMID:  19875869     Owner:  NLM     Status:  MEDLINE    
Reducing the size of low-solubility iron (Fe)-containing compounds to nanoscale has the potential to improve their bioavailability. Because Fe and zinc (Zn) deficiencies often coexist in populations, combined Fe/Zn-containing nanostructured compounds may be useful for nutritional applications. Such compounds are developed here and their solubility in dilute acid, a reliable indicator of iron bioavailability in humans, and sensory qualities in sensitive food matrices are investigated. Phosphates and oxides of Fe and atomically mixed Fe/Zn-containing (primarily ZnFe2O4) nanostructured powders were produced by flame spray pyrolysis (FSP). Chemical composition and surface area were systematically controlled by varying precursor concentration and feed rate during powder synthesis to increase solubility to the level of ferrous sulfate at maximum Fe and Zn content. Solubility of the nanostructured compounds was dependent on their particle size and crystallinity. The new nanostructured powders produced minimal color changes when added to dairy products containing chocolate or fruit compared to the changes produced when ferrous sulfate or ferrous fumarate were added to these foods. Flame-made Fe- and Fe/Zn-containing nanostructured powders have solubilities comparable to ferrous and Zn sulfate but may produce fewer color changes when added to difficult-to-fortify foods. Thus, these powders are promising for food fortification and other nutritional applications.
F M Hilty; A Teleki; F Krumeich; R B??chel; R F Hurrell; S E Pratsinis; M B Zimmermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-29
Journal Detail:
Title:  Nanotechnology     Volume:  20     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  England    
Other Details:
Languages:  eng     Pagination:  475101     Citation Subset:  IM    
Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland.
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MeSH Terms
Biological Availability
Biosensing Techniques
Ferric Compounds / chemistry
Food Technology / methods*
Iron / chemistry*,  pharmacokinetics
Microscopy, Electron, Transmission
Microscopy, Scanning Tunneling
Nanostructures / chemistry*
Nutritional Sciences*
Particle Size
Phosphates / analysis
Surface Properties
X-Ray Diffraction
Zinc / chemistry*,  pharmacokinetics
Zinc Oxide / chemistry
Reg. No./Substance:
0/Ferric Compounds; 0/Phosphates; 0/Powders; 1309-37-1/ferric oxide; 1314-13-2/Zinc Oxide; 7439-89-6/Iron; 7440-66-6/Zinc

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