| Development of novel thioguanosine analogs with the ability to specifically modify cytidine. | |
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MedLine Citation:
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PMID: 18029558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Site-specific modification of nucleic acid is of great significance in the machinery of gene expression. Specific modification of nucleic acids by an oligonucleotide incorporating a S-vinyl thioguanosine analog, has great potential as a useful tool. The specific transfer of the vinyl derivative to the amino group of dC at the target site of the complementary ODN has been demonstrated. This is an innovative method for the efficient and selective modification of the target cytidine in DNA. |
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Authors:
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Kazumitsu Onizuka; Yosuke Taniguchi; Shigeki Sasaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 5-6 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, CREST (JST). |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aniline Compounds
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chemistry Cytidine / chemistry* DNA / chemistry Thionucleosides / chemical synthesis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/3',5'-bis(tert-butyldimethylsilyl)-S-(2-benzoyl-3-oxo-2-butenyl)thioguanine; 0/3',5'-bis(tert-butyldimethylsilyl)-S-(4-nitrobenzoylvinyl)thioguanine; 0/3',5'-bis(tert-butyldimethylsilyl)-S-(benzoylvinyl)thioguanine; 0/Aniline Compounds; 0/Thionucleosides; 62-53-3/aniline; 65-46-3/Cytidine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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