Document Detail


Development of a novel soft hydrogel for the transdermal delivery of testosterone.
MedLine Citation:
PMID:  12602497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A soft hydrogel formulation for the transdermal delivery of testosterone (TS) was developed, and the effect of various skin-permeation enhancers was studied in vitro and in vivo. Testosterone was incorporated into a polyvinyl alcohol (PVA)-based soft hydrogel with polyisobutylene (PIB) and various skin-permeation enhancers (dodecylamine, HPE101, oleic acid, or lauric acid). In vitro rat-skin permeation of TS from the soft hydrogel was investigated using Keshary-Chien diffusion cells for 24 hr at 37 degrees C. In vivo plasma-concentration profiles of TS after applying the soft hydrogel on the dorsal skin of rat were determined using a commercial radioimmunoassay kit. The formulated soft hydrogel formed a thin film on the skin within 2 to 3 min after application and remained in a dried-film state for at least 24 hr. Addition of PIB into the hydrogel to increase the adhesion resulted in a negligible reduction in the skin-permeation rate of TS. However, rat-skin permeation of TS increased with the addition of permeation enhancers both in vitro and in vivo. Dodecylamine at the concentration of 3% was the most effective among tested. Plasma concentration of TS significantly increased for at least 24 hr with the addition of dodecylamine. These results suggest the feasibility of the development of a soft hydrogel formulation for the transdermal delivery of TS.
Authors:
Na-Mi An; Dae-Duk Kim; Young-Hee Shin; Chi-Ho Lee
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  29     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Pusan National University, Pusan, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adhesives
Adjuvants, Pharmaceutic
Administration, Cutaneous
Amines
Animals
Area Under Curve
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Drug Compounding
Hydrogels
Male
Polyenes
Polymers
Polyvinyl Alcohol*
Rats
Rats, Sprague-Dawley
Skin Absorption / drug effects
Testosterone / administration & dosage*,  chemistry*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Adhesives; 0/Adjuvants, Pharmaceutic; 0/Amines; 0/Delayed-Action Preparations; 0/Hydrogels; 0/Polyenes; 0/Polymers; 124-22-1/dodecylamine; 58-22-0/Testosterone; 9002-89-5/Polyvinyl Alcohol; 9003-27-4/polyisobutylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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