| Development of novel fast-disintegrating tablets by direct compression using sucrose stearic acid ester as a disintegration-accelerating agent. | |
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MedLine Citation:
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PMID: 18827375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It was attempted to produce novel furosemide (FS) fast-disintegrating tablets by direct compression. The combination of FS, microcrystalline cellulose, croscarmellose sodium and xylitol was used as the basic formulation, and sucrose stearic acid ester (SSE) was chosen as an additional additive. The tablets with SSE were prepared by the simple addition of SSE, using a lyophilized mixture of FS and SSE or using a FS/SSE mixture obtained by evaporation of their ethanol solution. Only the tablets, produced using the FS/SSE mixture obtained by organic solvent (ethanol) evaporation, showed hardness of more than 30 N and a disintegration time of less than 20 s, which were the properties suitable for fast-disintegrating tablets. These properties were considered to result from well-mixed and fine-powdered SSE and FS. |
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Authors:
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Takuma Koseki; Hiraku Onishi; Yuri Takahashi; Minoru Uchida; Yoshiharu Machida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 56 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2008-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1384-8 Citation Subset: IM |
Affiliation:
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Department of Drug Delivery Research, Hoshi University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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administration & dosage,
chemistry Carboxymethylcellulose Cellulose Chemistry, Pharmaceutical Diuretics / administration & dosage, chemistry Drug Compounding Esters / chemistry Ethanol / chemistry Excipients Flavoring Agents / pharmacology Furosemide / administration & dosage, chemistry Microscopy, Electron, Scanning Solubility Solvents Stearic Acids / chemistry* Sucrose / chemistry* Tablets Xylitol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Diuretics; 0/Esters; 0/Excipients; 0/Flavoring Agents; 0/Solvents; 0/Stearic Acids; 0/Tablets; 0/microcrystalline cellulose; 54-31-9/Furosemide; 57-11-4/stearic acid; 57-50-1/Sucrose; 64-17-5/Ethanol; 87-99-0/Xylitol; 9004-32-4/Carboxymethylcellulose; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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