Document Detail

Development of novel covered stents using salmon collagen.
MedLine Citation:
PMID:  19330508     Owner:  NLM     Status:  MEDLINE    
In this study, we newly developed self-expandable or balloon-expandable covered stents with a biodegradable salmon collagen (SC) film. The SC-covered stents were fabricated by placing a bare stent in a mixture of acidic SC solution and a fibrillogenesis-inducing buffer (pH 6.8) including a cross-linking agent (water-soluble carbodiimide), and subsequent incubation at 4 degrees C for 24 h and lyophilization. The stents obtained were completely covered with an SC film having a nanofibrous structure (fibril diameter, about 70 nm). On immersion in water, the film is converted to a gel with slight swelling. There was no rupture of the SC cover after mounting on a balloon catheter or after expansion. Preliminary implantation was conducted by placing the balloon-expandable covered stents in the common carotid arteries of beagles. One month after implantation, angiography showed that all stented arteries were patent with no significant neointimal thickening. In conclusion, SC is potentially useful as a cover material of endovascular stents to enhance patency.
Nobuhiro Nagai; Yasuhide Nakayama; Shogo Nishi; Masanobu Munekata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-29
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  12     ISSN:  1619-0904     ISO Abbreviation:  J Artif Organs     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Creative Research Initiative Sousei, Hokkaido University, Kita-ku, Sapporo, Japan.
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MeSH Terms
Carotid Artery, Common / surgery
Prosthesis Design*
Prosthesis Implantation
Tensile Strength
Reg. No./Substance:

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