| Development of a novel calcified total occlusion model in porcine coronary arteries. | |
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MedLine Citation:
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PMID: 18523324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to create a calcified total occlusion model in porcine coronary arteries using a catheter-based technique. BACKGROUND: Chronic total occlusion (CTO) represents 10-20% of all angioplasty cases and remains a challenge for interventional cardiologists. One of the limitations to successful recanalization is the failure to cross the wire through the CTOs. METHODS: Twenty swine underwent total occlusion creations in the coronary arteries. Via a carotid artery, previously prepared bone chips with absorbable sponge were delivered into the coronary arteries using catheter-based techniques. Twenty-eight days post creation, coronary angiography and histology were performed. RESULTS: Twelve animals survived and 10/12 had successful total occlusions. There were successful total occlusions in 100% (8/8) of the left anterior descending coronary arteries in the animals that survived. Angiography showed visible calcified total occlusions under fluoroscopy and also showed bridge collaterals distal to the occlusions (4/8) or contralateral collaterals from the right coronary arteries (4/8). The histology showed calcified nodules and abundant microchannels within the occlusions, media, and adventitia. CONCLUSIONS: We could successfully create a reliable and repeatable porcine coronary model of calcified total occlusions. This method can be utilized in many preclinical evaluations of CTO technologies. |
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Authors:
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Kaori Suzuki; Naritatsu Saito; Geping Zhang; Gerard Conditt; Jennifer McGregor; Alyssa M Flynn; Danielle Leahy; Patricia Glennon; Martin B Leon; Motoya Hayase |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 20 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-04 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 296-301 Citation Subset: IM |
Affiliation:
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Jack H. Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY 10962, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Animals Atenolol Calcinosis / physiopathology*, therapy Coronary Angiography Coronary Occlusion / physiopathology*, therapy Coronary Vessels / physiopathology* Disease Models, Animal Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 29122-68-7/Atenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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