| Development of a novel animal burn model using radiant heat in rats and swine. | |
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MedLine Citation:
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PMID: 20536806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objective was to develop a novel animal model of burns in rats and pigs. METHODS: The model uses heat that is delivered via a radiant heater with an opening of 5 cm by 5 cm, set at 400 degrees C, for 20 seconds. An advantage of this model is that the heating source does not come into direct contact with the animal, and the heat dispersion surrounding its center is very constant. The device was evaluated in 40 rats and seven pigs. With rats, three to four burns were created on each rat, resulting in a burn covering a total body surface area of 30% to 50%. In pigs, 16 burns were created on each animal. RESULTS: In rats, infliction of burns resulted in mortality rates of 0%-50% depending on the size of the burns and the rats. In pigs, the burns reepithelialized within approximately 3 weeks and resulted in hourglass contracted scars in two of three burns within 1 month. CONCLUSIONS: The authors describe a novel animal burn model that utilizes radiant heat to create consistent burns that maximizes safety to the investigators and animals. |
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Authors:
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Reuven Gurfinkel; Adam J Singer; Emanuela Cagnano; Lior Rosenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Volume: 17 ISSN: 1553-2712 ISO Abbreviation: Acad Emerg Med Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9418450 Medline TA: Acad Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 514-20 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery Soroka University Medical Center, Beer-Sheva, Israel. jaba1234@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Surface Area Burns* / mortality Confidence Intervals Disease Models, Animal* Prospective Studies Rats Swine |
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