Document Detail

Development of a noninvasive method to measure intravascular and intracardiac pressure differences using magnetic resonance imaging.
MedLine Citation:
PMID:  18827454     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We developed a noninvasive method using magnetic resonance (MR) imaging to measure differences in intravascular and intracardiac pressure, and we investigated the feasibility of the method's use in a pulsatile flow phantom and human studies. METHODS: We measured 3 velocity components using phase contrast MR imaging on a 1.5T MR scanner, used velocity data in Navier-Stokes equations to obtain pressure gradients, and directly integrated the in-plane pressure gradients to calculate pressure differences. To validate our method, we compared the pressure differences obtained by our method with the theoretical values obtained from an axisymmetric model of arterial stenosis. We also estimated the pressure differences in glass-tube phantoms simulating various vascular pathologies and in the left ventricle and aortic arch of a normal volunteer as clinical application. RESULTS: The pressure differences obtained by our method agreed well with theoretical values obtained using the straight-tube phantom with stenosis of 45%, but we observed some differences when stenosis was 65%. We clearly observed variations in pressure differences at specific locations at various phases of a cardiac cycle in both phantom and human studies. CONCLUSION: This method appears useful for measuring intravascular and intracardiac pressure differences.
Taisuke Nagao; Keita Yoshida; Koji Okada; Shohei Miyazaki; Takashi Ueguchi; Kenya Murase
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     Volume:  7     ISSN:  1347-3182     ISO Abbreviation:  Magn Reson Med Sci     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101153368     Medline TA:  Magn Reson Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Course of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
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MeSH Terms
Aorta / anatomy & histology*,  physiology*
Blood Pressure Determination / methods*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging, Cine / instrumentation,  methods*
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity

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