Document Detail

Development of newborn and infant vaccines.
MedLine Citation:
PMID:  21734174     Owner:  NLM     Status:  MEDLINE    
Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.
Guzman Sanchez-Schmitz; Ofer Levy
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Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science translational medicine     Volume:  3     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-07     Completed Date:  2011-11-15     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90ps27     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Communicable Disease Control
Immune System / immunology*
Infant, Newborn / immunology*
Vaccines / immunology*
Grant Support
3R01AI067353-05S1/AI/NIAID NIH HHS; P51 RR000168/RR/NCRR NIH HHS; R01 AI067353/AI/NIAID NIH HHS; R01 AI067353-01A1/AI/NIAID NIH HHS
Reg. No./Substance:

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